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IPR042199 is a Aspartokinase/Bifunctional aspartokinase/homoserine dehydrogenase, catalytic domain.
<p>Aspartokinase is the first enzyme in the aspartate metabolic pathway and catalyzes the conversion of aspartate and ATP to aspartylphosphate and ADP. In Bacillus subtilis, YclM is reported to be a single polypeptide of 50 kD. The B. subtilis 168 AKIII is induced by lysine and repressed by threonine, and it is synergistically inhibited by lysine and threonine [[cite:PUB00086232], [cite:PUB00086233]].</p> <p>The bifunctional enzyme aspartokinase/homoserine dehydrogenase (AK-HSDH), found in bacteria and plant chloroplasts, catalyses the first and third steps of the aspartate pathway. Homoserine dehydrogenase ([ec:1.1.1.3]) catalyses the conversion of L-homoserine to L-aspartate-4-semialdehyde using NAD(P), while aspartate kinase ([ec:2.7.2.4]) catalyses the phosphorylation of L-aspartate to 4-phospho-L-aspartate. There are two genes encoding different isoforms of this bifunctional enzymes; one isoform is threonine-sensitive, while the other is methionine-sensitive [[cite:PUB00014809]].</p> <p>This superfamily represents the N-terminal catalytic domain found in aspartokinase and in the bifunctional enzyme aspartokinase/homoserine dehydrogenase. It has a key role in amino acid binding.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|A0A0R0FVM5|A0A0R0FVM5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0632300 | 19 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|A0A0R0FVM5|A0A0R0FVM5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0632300 | 19 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q0S5|A0A0B2Q0S5_GLYSO Aspartokinase 1, chloroplastic; Found in the gene: LotjaGi2g1v0104400 | 20 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|I1MNP0|I1MNP0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0104400 | 20 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|I1MNP0|I1MNP0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0104400 | 19 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|I1MNP0|I1MNP0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0104400 | 20 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q0S5|A0A0B2Q0S5_GLYSO Aspartokinase 1, chloroplastic; Found in the gene: LotjaGi2g1v0104400 | 20 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|I1MNP0|I1MNP0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0104400 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04933 | CDD | 1 | 12.50 |