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IPR018042 is a Aspartate kinase, conserved site.
<p>Aspartate kinase ([ec:2.7.2.4]) (AK) catalyzes the first reaction in the aspartate pathway; the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine [[cite:PUB00002476]].</p> <p>In bacteria there are three different aspartate kinase isozymes which differ in sensitivity to repression and inhibition by Lys, Met and Thr. AK1 and AK2 are bifunctional enzymes which both consist of an N-terminal AK domain and a C-terminal homoserine dehydrogenase domain. AK1 is involved in threonine biosynthesis and AK2, in that of methionine. The third isozyme, AK3 is monofunctional and involved in lysine synthesis. In archaea and plants there may be a single isozyme of AK which in plants is multifunctional.</p> <p>This entry represents a region encoding aspartate kinase activity found in both the monofunctional and bifunctional enzymes.</p> <p>Synonym(s): Aspartokinase</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aspartate kinase activity | Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+). | ||
| Biological process | Cellular amino acid biosynthetic process | The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: aspartokinase 1, chloroplastic-like [Glycine max] gi|356570251|ref|XP_003553303.1| | 13 | ||
| – | PREDICTED: bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like [Cicer arietinum] gi|502140918|ref|XP_004504375.1| | 30 | ||
| – | PREDICTED: bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like isoform X1 [Cicer arietinum] gi|502135208|ref|XP_004502255.1| | 33 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|A0A0R0FVM5|A0A0R0FVM5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0632300 | 19 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|A0A0R0FVM5|A0A0R0FVM5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0632300 | 19 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q0S5|A0A0B2Q0S5_GLYSO Aspartokinase 1, chloroplastic; Found in the gene: LotjaGi2g1v0104400 | 20 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|I1MNP0|I1MNP0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0104400 | 20 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|I1MNP0|I1MNP0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0104400 | 19 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|I1MNP0|I1MNP0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0104400 | 20 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q0S5|A0A0B2Q0S5_GLYSO Aspartokinase 1, chloroplastic; Found in the gene: LotjaGi2g1v0104400 | 20 | ||
| – | Aspartokinase; TAIR: AT5G13280.1 aspartate kinase 1; Swiss-Prot: sp|Q9LYU8|AK1_ARATH Aspartokinase 1, chloroplastic; TrEMBL-Plants: tr|I1MNP0|I1MNP0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0104400 | 20 | ||
| – | Aspartokinase-homoserine dehydrogenase; TAIR: AT4G19710.2 aspartate kinase-homoserine dehydrogenase ii; Swiss-Prot: sp|P37142|AKH_DAUCA Bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic; TrEMBL-Plants: tr|I1K3R3|I1K3R3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0370400 | 33 | ||
| – | Retrovirus-related Pol polyprotein from transposon TNT 1-94; TAIR: AT4G23160.2 cysteine-rich RECEPTOR-like kinase; Swiss-Prot: sp|P04146|COPIA_DROME Copia protein; TrEMBL-Plants: tr|A0A151R7A9|A0A151R7A9_CAJCA Retrovirus-related Pol polyprotein from transposon TNT 1-94; Found in the gene: LotjaGi5g1v0001100_LC | 7 | ||
| – | Aspartokinase-homoserine dehydrogenase; TAIR: AT4G19710.2 aspartate kinase-homoserine dehydrogenase ii; Swiss-Prot: sp|O81852|AKH2_ARATH Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; TrEMBL-Plants: tr|G7JAT7|G7JAT7_MEDTR Aspartokinase-homoserine dehydrogenase; Found in the gene: LotjaGi6g1v0041900 | 34 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04922 | CDD | 1 | 7.14 |