Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR042487 is a RuvBL1/2, DNA/RNA binding domain.
<p>RuvBL1 is a ubiquitously expressed protein that plays important roles in chromatin remodeling, transcription, DNA repair, and apoptosis. The significant evolutionary conservation of RuvBL1 from yeast to man strongly suggests that it mediates important cellular functions. RuvBL1 belongs to a large family of ATPases known as AAA proteins (ATPases associated with diverse cellular activities) which generally form hexamers. RuvBL1 is the eukaryotic homologue of the bacterial DNA-dependent ATPase and helicase RuvB [[cite:PUB00039942]].</p> <p>RuvB-like helicase 2 (RUVBL2 or TIP49b; [ec:3.6.4.12]) has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It forms a homohexamer which is critical for ATP hydrolysis, and forms a dodecamer with RUVBL1 [[cite:PUB00087896], [cite:PUB00087897]]. RUVBL2 is an essential cofactor for oncogenic transformation by c-Myc [[cite:PUB00087898]]. It is a component of the NuA4 histone acetyltransferase [[cite:PUB00087899]], BAF53 [[cite:PUB00087900]], MLL1/MLL [[cite:PUB00063002]], INO80 [[cite:PUB00061630]] and R2TP [[cite:PUB00087901]] complexes.</p> <p>This entry represents the second domain of RuvBL1 and RUVB2 which is involved in DNA/RNA binding [[cite:PUB00039942]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|Q9M3Z6|Q9M3Z6_CICAR RuvB-like helicase; Found in the gene: LotjaGi1g1v0016800 | 14 | ||
| – | RuvB-like helicase; TAIR: AT5G67630.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9DE27|RUVB2_XENLA RuvB-like 2; TrEMBL-Plants: tr|G7J268|G7J268_MEDTR RuvB-like helicase; Found in the gene: LotjaGi6g1v0135200 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00009 | CDD | 1 | 50.00 |