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IPR010339

Source: InterPro

Description

IPR010339 is a TIP49, P-loop domain.

<p>This entry represents the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the AAA ATPase, central region [interpro:IPR003959] domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [[cite:PUB00012248]]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities. TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [[cite:PUB00012249]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003678
Molecular function DNA helicase activity Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
Subterm of
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of

Associated Lotus transcripts 21

Transcript Name Description Predicted domains Domain count
Lj0g3v0072209.1
– PREDICTED: ruvB-like 2-like, partial [Vitis vinifera] gi|359496414|ref|XP_003635231.1|
Domains
7
Lj0g3v0116309.1
– PREDICTED: ruvB-like 1-like [Cicer arietinum] gi|502132683|ref|XP_004501479.1|
Domains
10
Lj0g3v0116319.1
– PREDICTED: ruvB-like 1-like [Glycine max] gi|356526125|ref|XP_003531670.1|
Domains
8
Lj0g3v0204609.1
– RuvB-like helicase [Medicago truncatula] gi|357497063|ref|XP_003618820.1|
Domains
6
Lj1g3v2143350.1
– PREDICTED: ruvB-like 1-like [Glycine max] gi|356526125|ref|XP_003531670.1|
Domains
16
Lj6g3v0635320.1
– RuvB DNA helicase-like protein [Medicago truncatula] gi|357460397|ref|XP_003600480.1|
Domains
11
LotjaGi1g1v0016800.1
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0016800
Domains
14
LotjaGi1g1v0016800.2
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0016800
Domains
19
LotjaGi1g1v0016800.3
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|Q9M3Z6|Q9M3Z6_CICAR RuvB-like helicase; Found in the gene: LotjaGi1g1v0016800
Domains
14
LotjaGi1g1v0016800.4
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0016800
Domains
19
LotjaGi1g1v0240100_LC.1
– RuvB-like helicase; TAIR: AT5G67630.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|P0CR29|RUVB2_CRYNB RuvB-like helicase 2; TrEMBL-Plants: tr|B9IFT1|B9IFT1_POPTR RuvB-like helicase; Found in the gene: LotjaGi1g1v0240100_LC
Domains
11
LotjaGi1g1v0240100_LC.2
– RuvB-like helicase; TAIR: AT5G67630.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|P0CR29|RUVB2_CRYNB RuvB-like helicase 2; TrEMBL-Plants: tr|B9IFT1|B9IFT1_POPTR RuvB-like helicase; Found in the gene: LotjaGi1g1v0240100_LC
Domains
11
LotjaGi1g1v0240100_LC.3
– RuvB-like helicase; TAIR: AT5G67630.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|P0CR29|RUVB2_CRYNB RuvB-like helicase 2; TrEMBL-Plants: tr|B9IFT1|B9IFT1_POPTR RuvB-like helicase; Found in the gene: LotjaGi1g1v0240100_LC
Domains
11
LotjaGi1g1v0425600.1
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0425600
Domains
14
LotjaGi1g1v0425600.2
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0425600
Domains
19
LotjaGi1g1v0425600.3
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0425600
Domains
14
LotjaGi1g1v0425600.4
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0425600
Domains
19
LotjaGi1g1v0425600.5
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|A0A1J7HT38|A0A1J7HT38_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0425600
Domains
10
LotjaGi4g1v0370900_LC.1
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi4g1v0370900_LC
Domains
19
LotjaGi4g1v0370900_LC.2
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi4g1v0370900_LC
Domains
19
LotjaGi6g1v0135200.1
– RuvB-like helicase; TAIR: AT5G67630.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9DE27|RUVB2_XENLA RuvB-like 2; TrEMBL-Plants: tr|G7J268|G7J268_MEDTR RuvB-like helicase; Found in the gene: LotjaGi6g1v0135200
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00009 CDD 1 4.76