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IPR042530 is a EME1/EME2, C-terminal domain.
<p>This superfamily includes the C-terminal domain found in Eme1 from fission yeasts, and EME1/EME2 from animals. They interact with Mus81 to from a complex, which acts as a structure-specific endonuclease that targets branched DNA structures with a 5'-end at the branch nick [[cite:PUB00078392], [cite:PUB00078395]]. The typical substrates of this complex include 3'-flap structures, replication forks and nicked Holliday junctions [[cite:PUB00078394], [cite:PUB00078393]].</p> <p>Similar to MUS81-EME1, human MUS81-EME2 cleaves 3'-flaps, replication forks and nicked Holliday junctions, and exhibits limited endonuclease activity with intact Holliday junctions. However, MUS81-EME2 can also cleave a variety of DNA structures including D-loop recombination intermediates and nicked duplex [[cite:PUB00078396], [cite:PUB00078397]].</p> <p>Both Mus81 and Eme1 consist of a central nuclease domain, two repeats of the helix-hairpin-helix (HhH) motif at their C-terminal region, and a linker helix [[cite:PUB00050346]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Crossover junction endonuclease EME1; TAIR: AT2G22140.1 essential meiotic endonuclease 1B; Swiss-Prot: sp|C5H8J1|EME1B_ARATH Crossover junction endonuclease EME1B; TrEMBL-Plants: tr|G7LC63|G7LC63_MEDTR Crossover junction endonuclease EME1; Found in the gene: LotjaGi4g1v0405500 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |