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IPR042534 is a Sin3 associated polypeptide p18 superfamily.
<p>This superfamily includes several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides [[cite:PUB00012633]]. SAP18 (UBL domain) is one of the three three ASAP subunits (along with Acinus (β-hairpin motif) and RNPS1 (RRM domain)) that play a role in programmed cell death, transcriptional regulation, pre-mRNA splicing and mRNA quality control [[cite:PUB00012634], [cite:PUB00058275]]. The ASAP complex interacts with the exon-junction complex (EJC), a messenger ribonucleoprotein complex involved in post-transcriptional regulation [[cite:PUB00058275]].</p> <p>The high degree of evolutionary conservation and the fortuitous crystal contacts at the α-β groove suggest that this surface of SAP18 is a hot spot for interactions. Possible binding partners targeting this surface of SAP18 are transcription factors (such as Bicoid and Kruppel) and/or Sin3a-HDAC subunits.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Histone deacetylase complex subunit SAP18; TAIR: AT2G45640.1 SIN3 associated polypeptide P18; Swiss-Prot: sp|O64644|SAP18_ARATH Histone deacetylase complex subunit SAP18; TrEMBL-Plants: tr|V7ANN3|V7ANN3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0374100 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |