Description

IPR043510 is a 5MP1/2, W2 domain.

<p>The W2 domain has a globular fold and is exclusively composed out of α-helices [[cite:PUB00022408], [cite:PUB00040819], [cite:PUB00041778]]. The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core contains two aromatic/acidic residue-rich regions (AA boxes), which are important for mediating protein-protein interactions. The structure of this C-terminal W2 domain resembles that of a set of concatenated HEAT repeats [[cite:PUB00035800], [cite:PUB00094127], [cite:PUB00094128]]</p> <p>eIF5-mimic proteins 1 and 2 5MP1 and 5MP2 (also known as basic leucine zipper and W2 domain-containing proteins 1 and 2 (BZW1 and BZW2)) act as competitors of eIF5 and can inhibit general translation by interaction with eIF2 and inhibiting the tertiary complex binding to the ribosome [[cite:PUB00160139], [cite:PUB00160140]]. These translation regulatory proteins exist in nearly all eukaryotes except in nematodes, yeasts, and some protozoans. 5MP1/2 contain MA3- and W2-type ([interpro:IPR043510]) C-terminal HEAT domains that resemble the HEAT domain of eIF5 [[cite:PUB00094129]]. They enable cadherin binding activity [[cite:PUB00160429]]. The orthologue in Drosophila melanogaster, known as protein krasavietz (kra), is involved in several processes, including behavioural response to ethanol, long-term memory, and positive regulation of filopodium assembly. Kra is located in several cellular components, including the axonal growth cone, filopodium, and neuronal cell body [[cite:PUB00160428], [cite:PUB00160430]].</p> <p>The elf5-mimic protein family functions as translation initiation regulators. They are known to repress non-AUG-initiated translation and repeat-associated non-AUG (RAN)-initiated translation, acting as competitive inhibitors of eukaryotic translation initiation factor 5 (EIF5). These proteins increase the accuracy of translation initiation by competing with EIF5 for interaction with EIF2S2 within the 43S pre-initiation complex, in a manner dependent on binding to EIF3C. Additionally, some members of this family are involved in enhancing histone H4 gene transcription, although they do not directly bind to DNA [[cite:PUB00160432], [cite:PUB00095038], [cite:PUB00160431]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: