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IPR043510 is a BZW1/2, W2 domain.
<p>The eIF5-mimic protein 1/2 (also known as basic leucine zipper and W2 domain-containing proteins 2 and 1 (BZW2 and BZW1), respectively), are paralogous human proteins containing C-terminal HEAT domains that resemble the HEAT domain of eIF5 [[cite:PUB00094129]]. BZW1 plays an important role in the cell cycle and transcriptionally control the histone H4 gene during G1/S phase [[cite:PUB00094130]]. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal W2 domain resembles that of a set of concatenated HEAT repeats [[cite:PUB00035800], [cite:PUB00094127], [cite:PUB00094128]].</p> <p>The W2 domain has a globular fold and is exclusively composed out of α-helices [[cite:PUB00022408], [cite:PUB00040819], [cite:PUB00041778]]. The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core contains two aromatic/acidic residue-rich regions (AA boxes), which are important for mediating protein-protein interactions.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Basic leucine zipper and W2 domain-containing protein 2; TAIR: AT5G36230.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q91VK1|BZW2_MOUSE Basic leucine zipper and W2 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7GEE1|A0A1J7GEE1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485800 | 13 | ||
| – | Basic leucine zipper and W2 domain-containing protein 2; TAIR: AT5G36230.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZL42|BZW2_CHICK Basic leucine zipper and W2 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7GEE1|A0A1J7GEE1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485800 | 13 | ||
| – | Basic leucine zipper and W2 domain-containing protein 2; TAIR: AT5G36230.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9Y6E2|BZW2_HUMAN Basic leucine zipper and W2 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7GEE1|A0A1J7GEE1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485800 | 13 | ||
| – | Basic leucine zipper and W2 domain-containing protein 2; TAIR: AT5G36230.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q91VK1|BZW2_MOUSE Basic leucine zipper and W2 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7GEE1|A0A1J7GEE1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485800 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11560 | CDD | 1 | 25.00 |