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IPR003307 is a W2 domain.
<p>Translation initiation is a sophisticated, well regulated and highly coordinated cellular process in eukaryotes, in which at least 11 eukaryotic initiation factors (eIFs) are included. The W2 domain (two invariant tryptophans) is a region of ~165 amino acids which is found in the C terminus of the following eIFs [[cite:PUB00005748], [cite:PUB00035800], [cite:PUB00022408], [cite:PUB00040819], [cite:PUB00041778]]:</p> <ul><li>Eukaryotic translation initiation factor 2B epsilon (eIF-2B-epsilon).</li> <li>Eukaryotic translation initiation factor 4 gamma (eIF-4-gamma).</li> <li>Eukaryotic translation initiation factor 5 (eIF-5), a GTPase-activating protein (GAP) specific for eIF2.</li></ul> <p>The W2 domain has a globular fold and is exclusively composed out of α-helices [[cite:PUB00022408], [cite:PUB00040819], [cite:PUB00041778]]. The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core contains two aromatic/acidic residue-rich regions (AA boxes), which are important for mediating protein-protein interactions.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: translation initiation factor eIF-2B subunit epsilon-like [Cicer arietinum] gi|502124571|ref|XP_004498583.1| | 24 | ||
| – | PREDICTED: basic leucine zipper and W2 domain-containing protein 2-like [Cicer arietinum] gi|502105584|ref|XP_004492841.1| | 15 | ||
| – | Eukaryotic translation initiation factor [Medicago truncatula] gi|357508251|ref|XP_003624414.1| | 21 | ||
| – | PREDICTED: eukaryotic translation initiation factor 5-like [Glycine max] gi|356499628|ref|XP_003518639.1| | 19 | ||
| – | PREDICTED: translation initiation factor eIF-2B subunit epsilon-like [Cicer arietinum] gi|502124571|ref|XP_004498583.1| | 24 | ||
| – | Basic leucine zipper and W2 domain-containing protein 2; TAIR: AT5G36230.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q91VK1|BZW2_MOUSE Basic leucine zipper and W2 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7GEE1|A0A1J7GEE1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485800 | 13 | ||
| – | Basic leucine zipper and W2 domain-containing protein 2; TAIR: AT5G36230.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZL42|BZW2_CHICK Basic leucine zipper and W2 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7GEE1|A0A1J7GEE1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485800 | 13 | ||
| – | Basic leucine zipper and W2 domain-containing protein 2; TAIR: AT5G36230.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9Y6E2|BZW2_HUMAN Basic leucine zipper and W2 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7GEE1|A0A1J7GEE1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485800 | 13 | ||
| – | Basic leucine zipper and W2 domain-containing protein 2; TAIR: AT5G36230.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q91VK1|BZW2_MOUSE Basic leucine zipper and W2 domain-containing protein 2; TrEMBL-Plants: tr|A0A1J7GEE1|A0A1J7GEE1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485800 | 19 | ||
| – | Eukaryotic translation initiation factor 5; TAIR: AT1G36730.1 Translation initiation factor IF2/IF5; Swiss-Prot: sp|P48724|IF5_PHAVU Eukaryotic translation initiation factor 5; TrEMBL-Plants: tr|A0A0L9TDF5|A0A0L9TDF5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0544600 | 22 | ||
| – | Eukaryotic translation initiation factor 5; TAIR: AT1G36730.1 Translation initiation factor IF2/IF5; Swiss-Prot: sp|P48724|IF5_PHAVU Eukaryotic translation initiation factor 5; TrEMBL-Plants: tr|A0A0L9TDF5|A0A0L9TDF5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0544600 | 22 | ||
| – | Eukaryotic translation initiation factor 5; TAIR: AT1G36730.1 Translation initiation factor IF2/IF5; Swiss-Prot: sp|P48724|IF5_PHAVU Eukaryotic translation initiation factor 5; TrEMBL-Plants: tr|A0A0L9TDF5|A0A0L9TDF5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0544600 | 22 | ||
| – | Eukaryotic translation initiation factor 5; TAIR: AT1G36730.1 Translation initiation factor IF2/IF5; Swiss-Prot: sp|P48724|IF5_PHAVU Eukaryotic translation initiation factor 5; TrEMBL-Plants: tr|A0A0L9TDF5|A0A0L9TDF5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0544800 | 21 | ||
| – | Translation initiation factor eIF-2B subunit epsilon; TAIR: AT2G34970.1 Trimeric LpxA-like enzyme; Swiss-Prot: sp|P56287|EI2BE_SCHPO Probable translation initiation factor eIF-2B subunit epsilon; TrEMBL-Plants: tr|V7BQ00|V7BQ00_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0309800 | 25 | ||
| – | Translation initiation factor eIF-2B subunit epsilon; TAIR: AT2G34970.1 Trimeric LpxA-like enzyme; Swiss-Prot: sp|P56287|EI2BE_SCHPO Probable translation initiation factor eIF-2B subunit epsilon; TrEMBL-Plants: tr|V7BQ00|V7BQ00_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0309800 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.67 |