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| Field | Value |
|---|---|
| Namespace | Cellular component |
| Short description | Nuclear exosome (RNase complex) |
| Full defintion | A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
| Subterm of |
The relationship of GO:0000176 with other GO terms.
| Relationship type | GO terms |
|---|---|
| Is a | |
| Regulates | n.a. |
| Part of | |
| Positively regulates | n.a. |
| Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0000176, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
| Field | Value |
|---|---|
| PMID | The regulation and functions of the nuclear RNA exosome complex. Nat Rev Mol Cell Biol. 2016 Apr; 17 (4): 227–39.PMID: 26726035 The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes. The exosome has a central role in several aspects of RNA biogenesis, including RNA maturation and surveillance. Moreover, it is emerging as an important player in regulating the expression levels of specific mRNAs in response to environmental cues and during cell differentiation and development. Although the mechanisms by which RNA is targeted to (or escapes from) the exosome are still not fully understood, general principles have begun to emerge, which we discuss in this Review. In addition, we introduce and discuss novel, previously unappreciated functions of the nuclear exosome, including in transcription regulation and in the maintenance of genome stability. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| Transcript | Name | Description | GO terms | GO count |
|---|---|---|---|---|
| – | PREDICTED: exosome component 10-like isoform X1 [Cicer arietinum] gi|502107238|ref|XP_004493202.1| | 2 | ||
| – | 3'-5' exonuclease domain-containing family protein; TAIR: AT5G35910.1 Polynucleotidyl transferase, ribonuclease H fold protein with HRDC domain-containing protein; Swiss-Prot: sp|A9LLI7|RP6L2_ARATH Protein RRP6-like 2; TrEMBL-Plants: tr|A0A151TSU8|A0A151TSU8_CAJCA Exosome component 10; Found in the gene: LotjaGi1g1v0646900 | 2 | ||
| – | 3'-5' exonuclease domain-containing family protein; TAIR: AT5G35910.1 Polynucleotidyl transferase, ribonuclease H fold protein with HRDC domain-containing protein; Swiss-Prot: sp|A9LLI7|RP6L2_ARATH Protein RRP6-like 2; TrEMBL-Plants: tr|I1MW66|I1MW66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0108600 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
| GO term | Namespace | Name | Observations | Saturation (%) |
|---|---|---|---|---|
| Biological process | RNA processing | 1 | 33.33 |