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GO:0000178

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Exosome (RNase complex)
Full defintion A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Subterm of

Relationships

The relationship of GO:0000178 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
The regulation and functions of the nuclear RNA exosome complex.Kilchert C, Wittmann S, Vasiljeva L
Nat Rev Mol Cell Biol. 2016 Apr; 17 (4): 227–39.PMID: 26726035

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes. The exosome has a central role in several aspects of RNA biogenesis, including RNA maturation and surveillance. Moreover, it is emerging as an important player in regulating the expression levels of specific mRNAs in response to environmental cues and during cell differentiation and development. Although the mechanisms by which RNA is targeted to (or escapes from) the exosome are still not fully understood, general principles have begun to emerge, which we discuss in this Review. In addition, we introduce and discuss novel, previously unappreciated functions of the nuclear exosome, including in transcription regulation and in the maintenance of genome stability.

Associated Lotus transcripts 20

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0273479.1
– PREDICTED: exosome complex component RRP43-like [Glycine max] gi|356526509|ref|XP_003531860.1|
GO terms
3
Lj1g3v4407610.1
– PREDICTED: exosome complex component rrp4-like [Cicer arietinum] gi|502115055|ref|XP_004495115.1|
GO terms
2
Lj1g3v4753360.1
– PREDICTED: exosome complex component RRP45-like isoform X3 [Cicer arietinum] gi|502122025|ref|XP_004497542.1|
GO terms
2
Lj4g3v0987840.1
– PREDICTED: exosome complex component RRP43-like [Glycine max] gi|356526509|ref|XP_003531860.1|
GO terms
3
Lj5g3v1314600.1
– Nucleic acid-binding, OB-fold-like protein isoform 1 [Theobroma cacao] gi|508718921|gb|EOY10818.1|
GO terms
2
LotjaGi1g1v0536100.1
– Zinc finger C3H1 domain-containing protein, putative; TAIR: AT2G39580.2 zinc finger C3H1 domain protein; Swiss-Prot: sp|O60293|ZC3H1_HUMAN Zinc finger C3H1 domain-containing protein; TrEMBL-Plants: tr|K7MVC4|K7MVC4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0536100
GO terms
2
LotjaGi1g1v0731200.1
– Exosome complex component RRP4; TAIR: AT1G03360.1 ribosomal RNA processing 4; Swiss-Prot: sp|Q9ZVT7|RRP4_ARATH Exosome complex component RRP4 homolog; TrEMBL-Plants: tr|B7FL19|B7FL19_MEDTR Ribosomal RNA processing protein; Found in the gene: LotjaGi1g1v0731200
GO terms
2
LotjaGi1g1v0731200.2
– Exosome complex component RRP4; TAIR: AT1G03360.1 ribosomal RNA processing 4; Swiss-Prot: sp|Q9ZVT7|RRP4_ARATH Exosome complex component RRP4 homolog; TrEMBL-Plants: tr|B7FL19|B7FL19_MEDTR Ribosomal RNA processing protein; Found in the gene: LotjaGi1g1v0731200
GO terms
2
LotjaGi1g1v0741200.1
– Exosome complex component; TAIR: AT3G60500.1 3'-5'-exoribonuclease family protein; Swiss-Prot: sp|Q9M209|CER7_ARATH Exosome complex component RRP45B; TrEMBL-Plants: tr|G7IP72|G7IP72_MEDTR Exosome complex exonuclease RRP41; Found in the gene: LotjaGi1g1v0741200
GO terms
2
LotjaGi2g1v0298600.1
– Exosome complex component Rrp4; TAIR: AT2G25355.1 PNAS-3-like protein; Swiss-Prot: sp|Q7KWX9|EXOS3_DICDI Putative exosome complex component rrp40; TrEMBL-Plants: tr|I1JE93|I1JE93_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0298600
GO terms
2
LotjaGi2g1v0298600.2
– Exosome complex component Rrp4; TAIR: AT2G25355.1 PNAS-3-like protein; Swiss-Prot: sp|Q7KWX9|EXOS3_DICDI Putative exosome complex component rrp40; TrEMBL-Plants: tr|I1JE93|I1JE93_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0298600
GO terms
2
LotjaGi2g1v0298600.3
– Exosome complex component RRP40; TAIR: AT4G32175.1 PNAS-3-like protein; Swiss-Prot: sp|Q7KWX9|EXOS3_DICDI Putative exosome complex component rrp40; TrEMBL-Plants: tr|C6T951|C6T951_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0298600
GO terms
2
LotjaGi4g1v0121200.1
– Exosome complex component; TAIR: AT1G60080.1 3'-5'-exoribonuclease family protein; Swiss-Prot: sp|Q2KHU3|EXOS8_BOVIN Exosome complex component RRP43; TrEMBL-Plants: tr|A0A151QPU2|A0A151QPU2_CAJCA Exosome complex exonuclease RRP43; Found in the gene: LotjaGi4g1v0121200
GO terms
3
LotjaGi4g1v0121200.2
– Exosome complex component; TAIR: AT1G60080.1 3'-5'-exoribonuclease family protein; Swiss-Prot: sp|Q2KHU3|EXOS8_BOVIN Exosome complex component RRP43; TrEMBL-Plants: tr|A0A151QPU2|A0A151QPU2_CAJCA Exosome complex exonuclease RRP43; Found in the gene: LotjaGi4g1v0121200
GO terms
3
LotjaGi4g1v0121200.3
– Exosome complex component; TAIR: AT1G60080.1 3'-5'-exoribonuclease family protein; Swiss-Prot: sp|Q2KHU3|EXOS8_BOVIN Exosome complex component RRP43; TrEMBL-Plants: tr|A0A151QPU2|A0A151QPU2_CAJCA Exosome complex exonuclease RRP43; Found in the gene: LotjaGi4g1v0121200
GO terms
3
LotjaGi5g1v0205900.1
– Exosome complex component CSL4; TAIR: AT5G38890.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q9DAA6|EXOS1_MOUSE Exosome complex component CSL4; TrEMBL-Plants: tr|K7LJV1|K7LJV1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0205900
GO terms
3
LotjaGi6g1v0013300.1
– Exosome complex component; TAIR: AT1G60080.1 3'-5'-exoribonuclease family protein; Swiss-Prot: sp|Q96B26|EXOS8_HUMAN Exosome complex component RRP43; TrEMBL-Plants: tr|I1KWF8|I1KWF8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0013300
GO terms
3
LotjaGi6g1v0013300.2
– Exosome complex component; TAIR: AT1G60080.1 3'-5'-exoribonuclease family protein; Swiss-Prot: sp|Q2KHU3|EXOS8_BOVIN Exosome complex component RRP43; TrEMBL-Plants: tr|A0A151QPU2|A0A151QPU2_CAJCA Exosome complex exonuclease RRP43; Found in the gene: LotjaGi6g1v0013300
GO terms
3
LotjaGi6g1v0013300.3
– Exosome complex component; TAIR: AT1G60080.1 3'-5'-exoribonuclease family protein; Swiss-Prot: sp|Q96B26|EXOS8_HUMAN Exosome complex component RRP43; TrEMBL-Plants: tr|I1MA04|I1MA04_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0013300
GO terms
3
LotjaGi6g1v0013300.4
– Exosome complex component; TAIR: AT1G60080.1 3'-5'-exoribonuclease family protein; Swiss-Prot: sp|Q96B26|EXOS8_HUMAN Exosome complex component RRP43; TrEMBL-Plants: tr|I1KWF8|I1KWF8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0013300
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0006401
Biological process RNA catabolic process 1 5.00