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GO:0006270

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description DNA replication initiation
Full defintion The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
Subterm of

Relationships

The relationship of GO:0006270 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
ISBN

· ISBN: 0815316194

, · pages

PMID
Mechanisms for initiating cellular DNA replication.Bleichert F, Botchan MR, Berger JM
Science. 2017 Feb 24; 355 (6327): .PMID: 28209641

Cellular DNA replication factories depend on ring-shaped hexameric helicases to aid DNA synthesis by processively unzipping the parental DNA helix. Replicative helicases are loaded onto DNA by dedicated initiator, loader, and accessory proteins during the initiation of DNA replication in a tightly regulated, multistep process. We discuss here the molecular choreography of DNA replication initiation across the three domains of life, highlighting similarities and differences in the strategies used to deposit replicative helicases onto DNA and to melt the DNA helix in preparation for replisome assembly. Although initiators and loaders are phylogenetically related, the mechanisms they use for accomplishing similar tasks have diverged considerably and in an unpredictable manner.

Associated Lotus transcripts 48

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0041639.1
– PREDICTED: DNA replication licensing factor mcm5-A-like [Cicer arietinum] gi|502151329|ref|XP_004508387.1|
GO terms
6
Lj0g3v0041639.2
– PREDICTED: DNA replication licensing factor mcm5-A-like [Glycine max] gi|356562886|ref|XP_003549699.1|
GO terms
6
Lj0g3v0059679.1
– PREDICTED: DNA replication licensing factor mcm6-like [Cicer arietinum] gi|502140186|ref|XP_004504098.1|
GO terms
6
Lj0g3v0059679.2
– PREDICTED: DNA replication licensing factor mcm6-like [Cicer arietinum] gi|502140186|ref|XP_004504098.1|
GO terms
6
Lj0g3v0085309.1
– PREDICTED: DNA replication licensing factor mcm4-B-like [Glycine max] gi|356538731|ref|XP_003537854.1|
GO terms
5
Lj0g3v0085309.2
– PREDICTED: DNA replication licensing factor mcm4-B-like [Glycine max] gi|356538731|ref|XP_003537854.1|
GO terms
5
Lj0g3v0187359.1
– PREDICTED: DNA replication licensing factor MCM3 homolog [Cicer arietinum] gi|502141886|ref|XP_004504687.1|
GO terms
4
Lj0g3v0187369.1
– MCM3 protein [Pisum sativum] gi|3894099|emb|CAA10166.1|
GO terms
3
Lj0g3v0273649.1
– PREDICTED: cell division control protein 6 homolog [Cicer arietinum] gi|502129264|ref|XP_004500243.1|
GO terms
2
Lj1g3v3557050.1
–
GO terms
1
Lj1g3v3557060.1
– PREDICTED: cell division control protein 45 homolog [Cicer arietinum] gi|502100395|ref|XP_004491707.1|
GO terms
1
Lj1g3v4579080.3
– PREDICTED: DNA helicase MCM8-like [Cicer arietinum] gi|502111051|ref|XP_004493943.1|
GO terms
3
Lj1g3v4862820.1
– PREDICTED: protein PROLIFERA-like [Glycine max] gi|356505629|ref|XP_003521592.1|
GO terms
5
Lj2g3v0777180.2
– PREDICTED: DNA replication licensing factor mcm4-B-like [Glycine max] gi|356538731|ref|XP_003537854.1|
GO terms
3
Lj4g3v0258690.1
– PREDICTED: DNA replication licensing factor MCM3 homolog [Cicer arietinum] gi|502141886|ref|XP_004504687.1|
GO terms
4
Lj4g3v2263980.1
– PREDICTED: DNA replication licensing factor mcm2-like [Glycine max] gi|356521757|ref|XP_003529518.1|
GO terms
6
Lj6g3v2204750.1
– PREDICTED: DNA helicase MCM9-like [Cicer arietinum] gi|502079392|ref|XP_004486246.1|
GO terms
3
LotjaGi1g1v0559000.1
– Protein MCM10 like; TAIR: AT2G20980.1 minichromosome maintenance 10; Swiss-Prot: sp|Q0VBD2|MCM10_MOUSE Protein MCM10 homolog; TrEMBL-Plants: tr|A0A151RNG8|A0A151RNG8_CAJCA Protein MCM10 isogeny; Found in the gene: LotjaGi1g1v0559000
GO terms
3
LotjaGi1g1v0590100.1
– Cell division control protein 45-like protein; TAIR: AT3G25100.1 cell division cycle 45; Swiss-Prot: sp|O74113|CDC45_SCHPO Cell division control protein 45 homolog; TrEMBL-Plants: tr|W9RYN1|W9RYN1_9ROSA Cell division control protein 45-like protein; Found in the gene: LotjaGi1g1v0590100
GO terms
1
LotjaGi1g1v0631500_LC.1
– DNA helicase; TAIR: AT2G16440.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q5JKB0|MCM4_ORYSJ DNA replication licensing factor MCM4; TrEMBL-Plants: tr|A0A0L9V779|A0A0L9V779_PHAAN DNA helicase; Found in the gene: LotjaGi1g1v0631500_LC
GO terms
5
LotjaGi1g1v0693900.1
– DNA helicase; TAIR: AT3G09660.1 minichromosome maintenance 8; Swiss-Prot: sp|Q9SF37|MCM8_ARATH Probable DNA helicase MCM8; TrEMBL-Plants: tr|K7MYY7|K7MYY7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0693900
GO terms
3
LotjaGi1g1v0693900.2
– DNA helicase; TAIR: AT3G09660.1 minichromosome maintenance 8; Swiss-Prot: sp|Q9SF37|MCM8_ARATH Probable DNA helicase MCM8; TrEMBL-Plants: tr|K7MYY7|K7MYY7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0693900
GO terms
3
LotjaGi1g1v0693900.3
– DNA helicase; TAIR: AT3G09660.1 minichromosome maintenance 8; Swiss-Prot: sp|Q9SF37|MCM8_ARATH Probable DNA helicase MCM8; TrEMBL-Plants: tr|K7MYY7|K7MYY7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0693900
GO terms
3
LotjaGi1g1v0693900.4
– DNA helicase; TAIR: AT3G09660.1 minichromosome maintenance 8; Swiss-Prot: sp|Q9SF37|MCM8_ARATH Probable DNA helicase MCM8; TrEMBL-Plants: tr|K7MYY7|K7MYY7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0693900
GO terms
3
LotjaGi1g1v0693900.5
– DNA helicase; TAIR: AT3G09660.1 minichromosome maintenance 8; Swiss-Prot: sp|Q9SF37|MCM8_ARATH Probable DNA helicase MCM8; TrEMBL-Plants: tr|K7MYY7|K7MYY7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0693900
GO terms
3
LotjaGi1g1v0722700_LC.1
– DNA helicase; TAIR: AT2G16440.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q5JKB0|MCM4_ORYSJ DNA replication licensing factor MCM4; TrEMBL-Plants: tr|A0A1J7GYJ8|A0A1J7GYJ8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0722700_LC
GO terms
5
LotjaGi1g1v0722700_LC.3
– DNA helicase; TAIR: AT2G16440.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q5JKB0|MCM4_ORYSJ DNA replication licensing factor MCM4; TrEMBL-Plants: tr|A0A1J7GYJ8|A0A1J7GYJ8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0722700_LC
GO terms
5
LotjaGi1g1v0760100.1
– DNA helicase; TAIR: AT4G02060.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|B8BMI1|MCM7_ORYSI DNA replication licensing factor MCM7; TrEMBL-Plants: tr|I1JQR6|I1JQR6_SOYBN DNA helicase; Found in the gene: LotjaGi1g1v0760100
GO terms
5
LotjaGi1g1v0760100.2
– DNA helicase; TAIR: AT4G02060.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|B8BMI1|MCM7_ORYSI DNA replication licensing factor MCM7; TrEMBL-Plants: tr|I1JQR6|I1JQR6_SOYBN DNA helicase; Found in the gene: LotjaGi1g1v0760100
GO terms
5
LotjaGi2g1v0214600_LC.1
– DNA helicase; TAIR: AT2G16440.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q5JKB0|MCM4_ORYSJ DNA replication licensing factor MCM4; TrEMBL-Plants: tr|I1LJ93|I1LJ93_SOYBN DNA helicase; Found in the gene: LotjaGi2g1v0214600_LC
GO terms
5
LotjaGi2g1v0214600_LC.2
– DNA helicase; TAIR: AT2G16440.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q5JKB0|MCM4_ORYSJ DNA replication licensing factor MCM4; TrEMBL-Plants: tr|I1LJ93|I1LJ93_SOYBN DNA helicase; Found in the gene: LotjaGi2g1v0214600_LC
GO terms
5
LotjaGi3g1v0262900.1
– DNA helicase; TAIR: AT2G16440.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q0WVF5|MCM4_ARATH DNA replication licensing factor MCM4; TrEMBL-Plants: tr|A0A1J7GYJ8|A0A1J7GYJ8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0262900
GO terms
5
LotjaGi3g1v0262900.2
– DNA helicase; TAIR: AT2G16440.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q0WVF5|MCM4_ARATH DNA replication licensing factor MCM4; TrEMBL-Plants: tr|A0A1J7GYJ8|A0A1J7GYJ8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0262900
GO terms
5
LotjaGi4g1v0023500.1
– DNA helicase; TAIR: AT5G46280.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q9FL33|MCM3_ARATH DNA replication licensing factor MCM3; TrEMBL-Plants: tr|V7CNV8|V7CNV8_PHAVU DNA helicase; Found in the gene: LotjaGi4g1v0023500
GO terms
4
LotjaGi4g1v0023500.2
– DNA helicase; TAIR: AT5G46280.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q9FL33|MCM3_ARATH DNA replication licensing factor MCM3; TrEMBL-Plants: tr|V7CNV8|V7CNV8_PHAVU DNA helicase; Found in the gene: LotjaGi4g1v0023500
GO terms
4
LotjaGi4g1v0024000_LC.1
– DNA helicase; TAIR: AT5G46280.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q43704|MCM31_MAIZE DNA replication licensing factor MCM3 homolog 1; TrEMBL-Plants: tr|V7CNV8|V7CNV8_PHAVU DNA helicase; Found in the gene: LotjaGi4g1v0024000_LC
GO terms
4
LotjaGi4g1v0024100_LC.1
– DNA helicase; TAIR: AT5G46280.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|Q9FL33|MCM3_ARATH DNA replication licensing factor MCM3; TrEMBL-Plants: tr|A0A1J7GK28|A0A1J7GK28_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0024100_LC
GO terms
4
LotjaGi4g1v0283800.1
– DNA helicase; TAIR: AT2G07690.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|O80786|MCM5_ARATH DNA replication licensing factor MCM5; TrEMBL-Plants: tr|B3GNI3|B3GNI3_PEA DNA helicase; Found in the gene: LotjaGi4g1v0283800
GO terms
6
LotjaGi4g1v0332400.1
– DNA helicase; TAIR: AT1G44900.1 minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|B8BKI8|MCM2_ORYSI DNA replication licensing factor MCM2; TrEMBL-Plants: tr|V7C891|V7C891_PHAVU DNA helicase; Found in the gene: LotjaGi4g1v0332400
GO terms
6
LotjaGi6g1v0112500.1
– Cell division control 6; TAIR: AT1G07270.1 Cell division control, Cdc6; Swiss-Prot: sp|Q8W032|CDC6B_ARATH Cell division control protein 6 homolog B; TrEMBL-Plants: tr|I1KYU8|I1KYU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0112500
GO terms
2
LotjaGi6g1v0112500.2
– Cell division control 6; TAIR: AT1G07270.1 Cell division control, Cdc6; Swiss-Prot: sp|Q8W032|CDC6B_ARATH Cell division control protein 6 homolog B; TrEMBL-Plants: tr|I1KYU8|I1KYU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0112500
GO terms
2
LotjaGi6g1v0247200.1
– DNA helicase; TAIR: AT5G44635.1 minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|F4KAB8|MCM6_ARATH DNA replication licensing factor MCM6; TrEMBL-Plants: tr|A0A072TUF1|A0A072TUF1_MEDTR DNA helicase; Found in the gene: LotjaGi6g1v0247200
GO terms
6
LotjaGi6g1v0351000.1
– DNA helicase; TAIR: AT2G14050.1 minichromosome maintenance 9; Swiss-Prot: sp|F4IFF3|MCM9_ARATH Probable DNA helicase MCM9; TrEMBL-Plants: tr|K7M9S9|K7M9S9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0351000
GO terms
3
LotjaGi6g1v0351000.2
– DNA helicase; TAIR: AT2G14050.1 minichromosome maintenance 9; Swiss-Prot: sp|F4IFF3|MCM9_ARATH Probable DNA helicase MCM9; TrEMBL-Plants: tr|K7M9S9|K7M9S9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0351000
GO terms
3
LotjaGi6g1v0351000.3
– DNA helicase; TAIR: AT2G14050.1 minichromosome maintenance 9; Swiss-Prot: sp|F4IFF3|MCM9_ARATH Probable DNA helicase MCM9; TrEMBL-Plants: tr|K7M9S9|K7M9S9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0351000
GO terms
3
LotjaGi6g1v0351000.4
– DNA helicase; TAIR: AT2G14050.1 minichromosome maintenance 9; Swiss-Prot: sp|F4IFF3|MCM9_ARATH Probable DNA helicase MCM9; TrEMBL-Plants: tr|K7M9S9|K7M9S9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0351000
GO terms
3
LotjaGi6g1v0351000.5
– DNA helicase; TAIR: AT2G14050.1 minichromosome maintenance 9; Swiss-Prot: sp|F4IFF3|MCM9_ARATH Probable DNA helicase MCM9; TrEMBL-Plants: tr|K7M9S9|K7M9S9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0351000
GO terms
3
LotjaGi6g1v0351000.6
– DNA helicase; TAIR: AT2G14050.1 minichromosome maintenance 9; Swiss-Prot: sp|F4IFF3|MCM9_ARATH Probable DNA helicase MCM9; TrEMBL-Plants: tr|K7M9S9|K7M9S9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0351000
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0006270
Biological process DNA replication initiation 1 2.08