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GO:0006348

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Chromatin silencing at telomere
Full defintion Repression of transcription of telomeric DNA by altering the structure of chromatin.
Subterm of

Relationships

The relationship of GO:0006348 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity.Straight AF, Shou W, Dowd GJ, Turck CW, Deshaies RJ, Johnson AD, Moazed D
Cell. 1999 Apr 16; 97 (2): 245–56.PMID: 10219245

The Sir2 protein mediates gene silencing and repression of recombination at the rDNA repeats in budding yeast. Here we show that Sir2 executes these functions as a component of a nucleolar complex designated RENT (regulator of nucleolar silencing and telophase exit). Net1, a core subunit of this complex, preferentially cross-links to the rDNA repeats, but not to silent DNA regions near telomeres or to active genes, and tethers the RENT complex to rDNA. Net1 is furthermore required for rDNA silencing and nucleolar integrity. During interphase, Net1 and Sir2 colocalize to a subdomain within the nucleous, but at the end of mitosis a fraction of Sir2 leaves the nucleolus and disperses as foci throughout the nucleus, suggesting that the structure of rDNA silent chromatin changes during the cell cycle. Our findings suggest that a protein complex shown to regulate exit from mitosis is also involved in gene silencing.

Associated Lotus transcripts 2

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj2g3v2658290.1
– PREDICTED: histone acetyltransferase type B catalytic subunit-like [Glycine max] gi|356551642|ref|XP_003544183.1|
GO terms
4
LotjaGi1g1v0086700.1
– Histone acetyltransferase; TAIR: AT5G56740.1 histone acetyltransferase of the GNAT family 2; Swiss-Prot: sp|Q9FJT8|HATB_ARATH Histone acetyltransferase type B catalytic subunit; TrEMBL-Plants: tr|I1M828|I1M828_SOYBN Histone acetyltransferase; Found in the gene: LotjaGi1g1v0086700
GO terms
4

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0016573
Biological process Histone acetylation 1 50.00