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Field | Value |
---|---|
Namespace | Cellular component |
Short description | Mpp10 complex |
Full defintion | A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p. |
Subterm of |
The relationship of GO:0034457 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0034457, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | mah |
PMID | The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol Cell Biol. 2007 Aug; 27 (15): 5414–29.PMID: 17515605 The 90S preribosomal particle is required for the production of the 18S rRNA from a pre-rRNA precursor. Despite the identification of the protein components of this particle, its mechanism of assembly and structural design remain unknown. In this work, we have combined biochemical studies, proteomic techniques, and bioinformatic analyses to shed light into the rules of assembly of the yeast 90S preribosome. Our results indicate that several protein subcomplexes work as discrete assembly subunits that bind in defined steps to the 35S pre-rRNA. The assembly of the t-UTP subunit is an essential step for the engagement of at least five additional subunits in two separate, and mutually independent, assembling routes. One of these routes leads to the formation of an assembly intermediate composed of the U3 snoRNP, the Pwp2p/UTP-B, subunit and the Mpp10p complex. The other assembly route involves the stepwise binding of Rrp5p and the UTP-C subunit. We also report the use of a bioinformatic approach that provides a model for the topological arrangement of protein components within the fully assembled particle. Together, our data identify the mechanism of assembly of the 90S preribosome and offer novel information about its internal architecture. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
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– | PREDICTED: U3 small nucleolar ribonucleoprotein protein MPP10-like [Cicer arietinum] gi|502152331|ref|XP_004508876.1| | 4 | ||
– | PREDICTED: U3 small nucleolar ribonucleoprotein protein MPP10-like [Cicer arietinum] gi|502152331|ref|XP_004508876.1| | 4 | ||
– | U3 small nucleolar ribonucleoprotein protein MPP10; TAIR: AT5G66540.1 U3 small nucleolar ribonucleoprotein; Swiss-Prot: sp|O00566|MPP10_HUMAN U3 small nucleolar ribonucleoprotein protein MPP10; TrEMBL-Plants: tr|M1BJB9|M1BJB9_SOLTU U3 small nucleolar ribonucleoprotein protein MPP10; Found in the gene: LotjaGi4g1v0232200 | 4 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Cellular component | Mpp10 complex | 1 | 33.33 |