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Field | Value |
---|---|
Namespace | Biological process |
Short description | Interstrand cross-link repair |
Full defintion | Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. |
Subterm of |
The relationship of GO:0036297 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0036297, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
---|---|
GOC | vw |
PMID | The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast. Mol Cell Biol. 2012 Jan; 32 (2): 276–87.PMID: 22064477 Of the five human RecQ family helicases, RecQ4, BLM, and WRN suppress distinct genome instability-linked diseases with severe phenotypes, often with indeterminate etiologies. Here, we functionally define Hrq1, a novel orthologue of RecQ4 from fission yeast. Biochemical analysis of Hrq1 reveals a DEAH box- and ATP-dependent 3'-5' helicase activity on various DNA substrates, including bubbles but not blunt duplexes, characteristic of the RecQ family. Cells lacking Hrq1 suffer spontaneous genomic instability and, consequently, require homologous recombination repair and the DNA damage checkpoint for viability. Hrq1 supports the nucleotide excision repair of DNA damage caused by the chemotherapeutic agent cisplatin and, in certain genetic contexts, UV light. Genetic epistasis analyses reveal that Hrq1 acts parallel to the PCNA/Ubc13/Mms2-dependent postreplication repair (PRR) pathway. Thus, in hrq1Δ cells, lesions are channeled through the PRR pathway, yielding hyper-recombinant and mutator phenotypes; analogous defects may underlie the genetic instability and diseases associated with RecQ4 dysfunction. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | Coiled-coil domain-containing protein MTMR15 [Medicago truncatula] gi|357502889|ref|XP_003621733.1| | 2 | ||
– | Fanconi-associated nuclease 1 like; TAIR: AT1G48360.2 zinc ion binding/nucleic acid binding/hydrolase; Swiss-Prot: sp|Q5XVJ4|FAN1_ARATH Fanconi-associated nuclease 1 homolog; TrEMBL-Plants: tr|G7KUQ4|G7KUQ4_MEDTR Fanconi-associated nuclease-like protein; Found in the gene: LotjaGi1g1v0531200 | 2 | ||
– | E3 ubiquitin-protein ligase RFWD3; TAIR: AT5G03450.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q6PCD5|RFWD3_HUMAN E3 ubiquitin-protein ligase RFWD3; TrEMBL-Plants: tr|V7CZT3|V7CZT3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0687400 | 4 | ||
– | E3 ubiquitin-protein ligase RFWD3; TAIR: AT5G03450.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q6PCD5|RFWD3_HUMAN E3 ubiquitin-protein ligase RFWD3; TrEMBL-Plants: tr|V7CZT3|V7CZT3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0687400 | 4 | ||
– | E3 ubiquitin-protein ligase RFWD3; TAIR: AT5G03450.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q6PCD5|RFWD3_HUMAN E3 ubiquitin-protein ligase RFWD3; TrEMBL-Plants: tr|V7CZT3|V7CZT3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0687400 | 4 | ||
– | RING/U-box superfamily protein; TAIR: AT5G03450.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|D2HWM5|RFWD3_AILME E3 ubiquitin-protein ligase RFWD3; TrEMBL-Plants: tr|V7CZT3|V7CZT3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0687500 | 4 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Interstrand cross-link repair | 1 | 16.67 |