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Field | Value |
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Namespace | Biological process |
Short description | Error-prone translesion synthesis |
Full defintion | The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. |
Subterm of |
The relationship of GO:0042276 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0042276, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | jl |
PMID | Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J Biol Chem. 2001 Sep 21; 276 (38): 35644–51.PMID: 11485998 Most mutations after DNA damage in yeast Saccharomyces cerevisiae are induced by error-prone translesion DNA synthesis employing scRev1 and DNA polymerase zeta that consists of scRev3 and scRev7 proteins. Recently, the human REV1 (hREV1) and REV3 (hREV3) genes were identified, and their products were revealed to be involved in UV-induced mutagenesis, as observed for their yeast counterparts. Human REV7 (hREV7) was also cloned, and its product was found to interact with hREV3, but the biological function of hREV7 remained unknown. We report here the analyses of precise interactions in the human REV proteins. The interaction between hREV1 and hREV7 was identified by the yeast two-hybrid library screening using a bait of hREV7, which was confirmed by in vitro and in vivo binding assays. The homodimerization of hREV7 was also detected in the two-hybrid analysis. In addition, the precise domains for interaction between hREV7 and hREV1 or hREV3 and for hREV7 homodimerization were determined. Although hREV7 interacts with both hREV1 and hREV3, a stable complex formation of the three proteins was undetectable in vitro. These findings suggest the possibility that hREV7 might play an important role in regulating the enzymatic activities of hREV1 and hREV3 for mutagenesis in response to DNA damage. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: DNA repair protein REV1-like isoform X2 [Cicer arietinum] gi|502158837|ref|XP_004511297.1| | 4 | ||
– | PREDICTED: DNA repair protein REV1-like isoform X2 [Cicer arietinum] gi|502158837|ref|XP_004511297.1| | 4 | ||
– | DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300 | 4 | ||
– | DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300 | 4 | ||
– | DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300 | 4 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Error-prone translesion synthesis | 1 | 20.00 |