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Field | Value |
---|---|
Namespace | Biological process |
Short description | [2Fe-2S] cluster assembly |
Full defintion | The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. |
Subterm of |
The relationship of GO:0044571 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0044571, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
---|---|
GOC | vw |
PMID | Structure, function, and formation of biological iron-sulfur clusters. Annu Rev Biochem. 2005; 74 (): 247–81.PMID: 15952888 Iron-sulfur [Fe-S] clusters are ubiquitous and evolutionary ancient prosthetic groups that are required to sustain fundamental life processes. Owing to their remarkable structural plasticity and versatile chemical/electronic features [Fe-S] clusters participate in electron transfer, substrate binding/activation, iron/sulfur storage, regulation of gene expression, and enzyme activity. Formation of intracellular [Fe-S] clusters does not occur spontaneously but requires a complex biosynthetic machinery. Three different types of [Fe-S] cluster biosynthetic systems have been discovered, and all of them are mechanistically unified by the requirement for a cysteine desulfurase and the participation of an [Fe-S] cluster scaffolding protein. Important mechanistic questions related to [Fe-S] cluster biosynthesis involve the molecular details of how [Fe-S] clusters are assembled on scaffold proteins, how [Fe-S] clusters are transferred from scaffolds to target proteins, how various accessory proteins participate in [Fe-S] protein maturation, and how the biosynthetic process is regulated. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: cysteine desulfurase 1, mitochondrial-like isoform 1 [Glycine max] gi|356497029|ref|XP_003517367.1| | 3 | ||
– | Cysteine desulfurase IscS; TAIR: AT5G65720.1 nitrogen fixation S (NIFS)-like 1; Swiss-Prot: sp|O49543|MNIF1_ARATH Cysteine desulfurase, mitochondrial; TrEMBL-Plants: tr|A0A1J7FXI5|A0A1J7FXI5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0412800 | 3 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | [2Fe-2S] cluster assembly | 1 | 50.00 |