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Field | Value |
---|---|
Namespace | Biological process |
Short description | Replication fork protection |
Full defintion | Any process that prevents the collapse of stalled replication forks. |
Subterm of |
The relationship of GO:0048478 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0048478, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
---|---|
GOC | vw |
PMID | Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol Cell Biol. 2003 Nov; 23 (21): 7861–74.PMID: 14560029 The replication checkpoint is a dedicated sensor-response system activated by impeded replication forks. It stabilizes stalled forks and arrests division, thereby preserving genome integrity and promoting cell survival. In budding yeast, Tof1 is thought to act as a specific mediator of the replication checkpoint signal that activates the effector kinase Rad53. Here we report studies of fission yeast Swi1, a Tof1-related protein required for a programmed fork-pausing event necessary for mating type switching. Our studies have shown that Swi1 is vital for proficient activation of the Rad53-like checkpoint kinase Cds1. Together they are required to prevent fork collapse in the ribosomal DNA repeats, and they also prevent irreversible fork arrest at a newly identified hydroxyurea pause site. Swi1 also has Cds1-independent functions. Rad22 DNA repair foci form during S phase in swi1 mutants and to a lesser extent in cds1 mutants, indicative of fork collapse. Mus81, a DNA endonuclease required for recovery from collapsed forks, is vital in swi1 but not cds1 mutants. Swi1 is recruited to chromatin during S phase. We propose that Swi1 stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: chromosome segregation in meiosis protein 3-like [Cicer arietinum] gi|502144460|ref|XP_004505705.1| | 3 | ||
– | PREDICTED: chromosome segregation in meiosis protein 3-like [Cicer arietinum] gi|502144460|ref|XP_004505705.1| | 3 | ||
– | Gag polyprotein; TAIR: AT3G02820.1 zinc knuckle (CCHC-type) family protein; Swiss-Prot: sp|Q6DBR4|TIPIN_DANRE TIMELESS-interacting protein; TrEMBL-Plants: tr|A0A0L9V851|A0A0L9V851_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0529800 | 3 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Replication fork protection | 1 | 33.33 |