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Field | Value |
---|---|
Namespace | Biological process |
Short description | Actin filament severing |
Full defintion | The process in which an actin filament is broken down into smaller filaments. |
Subterm of |
The relationship of GO:0051014 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0051014, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | ai |
PMID | ADF/cofilin use an intrinsic mode of F-actin instability to disrupt actin filaments. J Cell Biol. 2003 Dec 8; 163 (5): 1057–66.PMID: 14657234 Proteins in the ADF/cofilin (AC) family are essential for rapid rearrangements of cellular actin structures. They have been shown to be active in both the severing and depolymerization of actin filaments in vitro, but the detailed mechanism of action is not known. Under in vitro conditions, subunits in the actin filament can treadmill; with the hydrolysis of ATP driving the addition of subunits at one end of the filament and loss of subunits from the opposite end. We have used electron microscopy and image analysis to show that AC molecules effectively disrupt one of the longitudinal contacts between protomers within one helical strand of F-actin. We show that in the absence of any AC proteins, this same longitudinal contact between actin protomers is disrupted at the depolymerizing (pointed) end of actin filaments but is prominent at the polymerizing (barbed) end. We suggest that AC proteins use an intrinsic mechanism of F-actin's internal instability to depolymerize/sever actin filaments in the cell. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | Villin; TAIR: AT2G29890.1 villin-like 1; Swiss-Prot: sp|O81643|VILI1_ARATH Villin-1; TrEMBL-Plants: tr|I1N029|I1N029_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0112900 | 2 | ||
– | Villin; TAIR: AT2G29890.1 villin-like 1; Swiss-Prot: sp|O81643|VILI1_ARATH Villin-1; TrEMBL-Plants: tr|I1N029|I1N029_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0112900 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Molecular function | Actin filament binding | 1 | 50.00 |