Gene Ontology — View

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GO:0055087

Overview

Field	Value
Namespace	Cellular component
Short description	Ski complex
Full defintion	A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.
Subterm of	GO:0032991 GO:0044444

Relationships

The relationship of GO:0055087 with other GO terms.

Relationship type	GO terms
Is a	GO:0032991 GO:0044444
Regulates	n.a.
Part of	n.a.
Positively regulates	n.a.
Negatively regulates	n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0055087, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
GOC	mcc
PMID	The yeast Ski complex is a hetero-tetramer.Synowsky SA, Heck AJ Protein Sci. 2008 Jan; 17 (1): 119–25.PMID: 18042677 The yeast Ski complex assists the exosome in the degradation of mRNA. The Ski complex consists of three components; Ski2, Ski3, and Ski8, believed to be present in a 1:1:1 stoichiometry. Measuring the mass of intact isolated endogenously expressed Ski complexes by native mass spectrometry we unambiguously demonstrate that the Ski complex has a hetero-tetrameric stoichiometry consisting of one copy of Ski2 and Ski3 and two copies of Ski8. To validate the stoichiometry of the Ski complex, we performed tandem mass spectrometry. In these experiments one Ski8 subunit was ejected concomitant with the formation of a Ski2/Ski3/Ski8 fragment, confirming the proposed stoichiometry. To probe the topology of the Ski complex we disrupted the complex and mass analyzed the thus formed subcomplexes, detecting Ski8-Ski8, Ski2-Ski3, Ski8-Ski2, and Ski8-Ski8-Ski2. Combining all data we construct an improved structural model of the Ski complex.

Field

Value

GOC

mcc

PMID

The yeast Ski complex is a hetero-tetramer.Synowsky SA, Heck AJ
Protein Sci. 2008 Jan; 17 (1): 119–25.PMID: 18042677

The yeast Ski complex assists the exosome in the degradation of mRNA. The Ski complex consists of three components; Ski2, Ski3, and Ski8, believed to be present in a 1:1:1 stoichiometry. Measuring the mass of intact isolated endogenously expressed Ski complexes by native mass spectrometry we unambiguously demonstrate that the Ski complex has a hetero-tetrameric stoichiometry consisting of one copy of Ski2 and Ski3 and two copies of Ski8. To validate the stoichiometry of the Ski complex, we performed tandem mass spectrometry. In these experiments one Ski8 subunit was ejected concomitant with the formation of a Ski2/Ski3/Ski8 fragment, confirming the proposed stoichiometry. To probe the topology of the Ski complex we disrupted the complex and mass analyzed the thus formed subcomplexes, detecting Ski8-Ski8, Ski2-Ski3, Ski8-Ski2, and Ski8-Ski8-Ski2. Combining all data we construct an improved structural model of the Ski complex.

Associated Lotus transcripts 3

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Transcript	Name	Description	GO terms	GO count
LotjaGi2g1v0462200.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Tetratricopeptide repeat-containing protein; TAIR: AT1G76630.2 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp\|F4I3Z5\|SKI3_ARATH Tetratricopeptide repeat protein SKI3; TrEMBL-Plants: tr\|K7K5N8\|K7K5N8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0462200	GO terms View details of GO:0006401 View details of GO:0055087	2
LotjaGi2g1v0462200.2 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Tetratricopeptide repeat-containing protein; TAIR: AT1G76630.2 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp\|F4I3Z5\|SKI3_ARATH Tetratricopeptide repeat protein SKI3; TrEMBL-Plants: tr\|K7K5N9\|K7K5N9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0462200	GO terms View details of GO:0006401 View details of GO:0055087	2
LotjaGi2g1v0462200.3 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Tetratricopeptide repeat-containing protein; TAIR: AT1G76630.2 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp\|F4I3Z5\|SKI3_ARATH Tetratricopeptide repeat protein SKI3; TrEMBL-Plants: tr\|K7K5N9\|K7K5N9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0462200	GO terms View details of GO:0006401 View details of GO:0055087	2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term	Namespace	Name	Observations	Saturation (%)
GO:0055087 View details of GO:0055087 AmiGO InterPro QuickGO	Cellular component	Ski complex	1	33.33