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Field | Value |
---|---|
Namespace | Cellular component |
Short description | Elongin complex |
Full defintion | A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits. |
Subterm of |
The relationship of GO:0070449 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0070449, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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PMID | The RNA polymerase II elongation complex. Annu Rev Biochem. 2003; 72 (): 693–715.PMID: 12676794 Synthesis of eukaryotic mRNA by RNA polymerase II is an elaborate biochemical process that requires the concerted action of a large set of transcription factors. RNA polymerase II transcription proceeds through multiple stages designated preinitiation, initiation, and elongation. Historically, studies of the elongation stage of eukaryotic mRNA synthesis have lagged behind studies of the preinitiation and initiation stages; however, in recent years, efforts to elucidate the mechanisms governing elongation have led to the discovery of a diverse collection of transcription factors that directly regulate the activity of elongating RNA polymerase II. Moreover, these studies have revealed unanticipated roles for the RNA polymerase II elongation complex in such processes as DNA repair and recombination and the proper processing and nucleocytoplasmic transport of mRNA. Below we describe these recent advances, which highlight the important role of the RNA polymerase II elongation complex in regulation of eukaryotic gene expression. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | Elongin-A [Medicago truncatula] gi|357459275|ref|XP_003599918.1| | 3 | ||
– | Elongin-A [Medicago truncatula] gi|357459275|ref|XP_003599918.1| | 3 | ||
– | RNA polymerase II transcription factor SIII (Elongin) subunit A; TAIR: AT2G42780.1 transcription elongation factor B polypeptide; Swiss-Prot: sp|Q09413|ELOA1_CAEEL Transcription elongation factor B polypeptide 3; TrEMBL-Plants: tr|I3S977|I3S977_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0170900 | 3 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Cellular component | Elongin complex | 1 | 33.33 |