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GO:0070918

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Production of small RNA involved in gene silencing by RNA
Full defintion The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease.
Subterm of

Relationships

The relationship of GO:0070918 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCmah
PMID
Origins and Mechanisms of miRNAs and siRNAs.Carthew RW, Sontheimer EJ
Cell. 2009 Feb 20; 136 (4): 642–55.PMID: 19239886

Over the last decade, approximately 20-30 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAs--short interfering RNAs (siRNAs) and microRNAs (miRNAs)--act in both somatic and germline lineages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids. Recent advances have revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access. Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment.

Associated Lotus transcripts

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

No transcripts are associated with this gene ontology identifier.