Gene Ontology — View

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GO:0071821

Overview

Field	Value
Namespace	Cellular component
Short description	FANCM-MHF complex
Full defintion	A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes.
Subterm of	GO:0032991 GO:0044451

Relationships

The relationship of GO:0071821 with other GO terms.

Relationship type	GO terms
Is a	GO:0032991 GO:0044451
Regulates	n.a.
Part of	n.a.
Positively regulates	n.a.
Negatively regulates	n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0071821, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
GOC	vw
PMID	A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.Yan Z, Delannoy M, Ling C, Daee D, Osman F, Muniandy PA, Shen X, Oostra AB, Du H, Steltenpool J, Lin T, Schuster B, Décaillet C, Stasiak A, Stasiak AZ, Stone S, Hoatlin ME, Schindler D, Woodcock CL, Joenje H, Sen R, de Winter JP, Li L, Seidman MM, Whitby MC, Myung K, Constantinou A, Wang W Mol Cell. 2010 Mar 26; 37 (6): 865–78.PMID: 20347428 FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. We find that MHF stimulates DNA binding and replication fork remodeling by FANCM. In the cell, FANCM and MHF are rapidly recruited to forks stalled by DNA interstrand crosslinks, and both are required for cellular resistance to such lesions. In vertebrates, FANCM-MHF associates with the Fanconi anemia (FA) core complex, promotes FANCD2 monoubiquitination in response to DNA damage, and suppresses sister-chromatid exchanges. Yeast orthologs of these proteins function together to resist MMS-induced DNA damage and promote gene conversion at blocked replication forks. Thus, FANCM-MHF is an essential DNA-remodeling complex that protects replication forks from yeast to human.

Field

Value

GOC

PMID

A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.Yan Z, Delannoy M, Ling C, Daee D, Osman F, Muniandy PA, Shen X, Oostra AB, Du H, Steltenpool J, Lin T, Schuster B, Décaillet C, Stasiak A, Stasiak AZ, Stone S, Hoatlin ME, Schindler D, Woodcock CL, Joenje H, Sen R, de Winter JP, Li L, Seidman MM, Whitby MC, Myung K, Constantinou A, Wang W
Mol Cell. 2010 Mar 26; 37 (6): 865–78.PMID: 20347428

FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. We find that MHF stimulates DNA binding and replication fork remodeling by FANCM. In the cell, FANCM and MHF are rapidly recruited to forks stalled by DNA interstrand crosslinks, and both are required for cellular resistance to such lesions. In vertebrates, FANCM-MHF associates with the Fanconi anemia (FA) core complex, promotes FANCD2 monoubiquitination in response to DNA damage, and suppresses sister-chromatid exchanges. Yeast orthologs of these proteins function together to resist MMS-induced DNA damage and promote gene conversion at blocked replication forks. Thus, FANCM-MHF is an essential DNA-remodeling complex that protects replication forks from yeast to human.

Associated Lotus transcripts 3

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Transcript	Name	Description	GO terms	GO count
Lj1g3v1441390.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Centromere protein S [Medicago truncatula] gi\|357464945\|ref\|XP_003602754.1\|	GO terms View details of GO:0071821	1
Lj1g3v1441390.2 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Centromere protein S [Medicago truncatula] gi\|357464945\|ref\|XP_003602754.1\|	GO terms View details of GO:0071821	1
LotjaGi1g1v0333200.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Centromere protein S; TAIR: AT5G50930.1 Histone superfamily protein; Swiss-Prot: sp\|Q8N2Z9\|CENPS_HUMAN Centromere protein S; TrEMBL-Plants: tr\|G7J3A4\|G7J3A4_MEDTR Transcription initiation factor IID, 31 kDa subunit; Found in the gene: LotjaGi1g1v0333200	GO terms View details of GO:0071821	1

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term	Namespace	Name	Observations	Saturation (%)
GO:0071821 View details of GO:0071821 AmiGO InterPro QuickGO	Cellular component	FANCM-MHF complex	1	33.33