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GO:0097361

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description CIA complex
Full defintion The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity.
Subterm of

Relationships

The relationship of GO:0097361 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCsp
PMID
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.Stehling O, Vashisht AA, Mascarenhas J, Jonsson ZO, Sharma T, Netz DJ, Pierik AJ, Wohlschlegel JA, Lill R
Science. 2012 Jul 13; 337 (6091): 195–9.PMID: 22678362

Instability of the nuclear genome is a hallmark of cancer and aging. MMS19 protein has been linked to maintenance of genomic integrity, but the molecular basis of this connection is unknown. Here, we identify MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery. MMS19 functions as part of the CIA targeting complex that specifically interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance. MMS19 thus serves as an adapter between early-acting CIA components and a subset of cellular iron-sulfur proteins. The function of MMS19 in the maturation of crucial components of DNA metabolism may explain the sensitivity of MMS19 mutants to DNA damage and the presence of extended telomeres.

Associated Lotus transcripts 2

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj1g3v4717280.1
– PREDICTED: probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog [Cicer arietinum] gi|502111819|ref|XP_004494174.1|
GO terms
2
LotjaGi1g1v0676000.1
– WD repeat-containing protein; TAIR: AT2G26060.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|O80990|CIA1_ARATH Protein CIA1; TrEMBL-Plants: tr|V7D053|V7D053_PHAVU Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; Found in the gene: LotjaGi1g1v0676000
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0097361
Cellular component CIA complex 1 50.00