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Field | Value |
---|---|
Namespace | Biological process |
Short description | TRNA-guanine transglycosylation |
Full defintion | The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. |
Subterm of |
The relationship of GO:0101030 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0101030, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | vw |
PMID | Plant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family. ACS Chem Biol. 2014 Aug 15; 9 (8): 1812–25.PMID: 24911101 Queuosine (Q) is a modification found at the wobble position of tRNAs with GUN anticodons. Although Q is present in most eukaryotes and bacteria, only bacteria can synthesize Q de novo. Eukaryotes acquire queuine (q), the free base of Q, from diet and/or microflora, making q an important but under-recognized micronutrient for plants, animals, and fungi. Eukaryotic type tRNA-guanine transglycosylases (eTGTs) are composed of a catalytic subunit (QTRT1) and a homologous accessory subunit (QTRTD1) forming a complex that catalyzes q insertion into target tRNAs. Phylogenetic analysis of eTGT subunits revealed a patchy distribution pattern in which gene losses occurred independently in different clades. Searches for genes co-distributing with eTGT family members identified DUF2419 as a potential Q salvage protein family. This prediction was experimentally validated in Schizosaccharomyces pombe by confirming that Q was present by analyzing tRNA(Asp) with anticodon GUC purified from wild-type cells and by showing that Q was absent from strains carrying deletions in the QTRT1 or DUF2419 encoding genes. DUF2419 proteins occur in most Eukarya with a few possible cases of horizontal gene transfer to bacteria. The universality of the DUF2419 function was confirmed by complementing the S. pombe mutant with the Zea mays (maize), human, and Sphaerobacter thermophilus homologues. The enzymatic function of this family is yet to be determined, but structural similarity with DNA glycosidases suggests a ribonucleoside hydrolase activity. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: queuine tRNA-ribosyltransferase-like [Glycine max] gi|356510157|ref|XP_003523806.1| | 2 | ||
– | PREDICTED: queuine tRNA-ribosyltransferase-like [Glycine max] gi|356510157|ref|XP_003523806.1| | 2 | ||
– | Queuine tRNA-ribosyltransferase; TAIR: AT1G72430.1 SAUR-like auxin-responsive protein family; Swiss-Prot: sp|Q28HC6|TGT_XENTR Queuine tRNA-ribosyltransferase catalytic subunit 1; TrEMBL-Plants: tr|A0A0R0JIE5|A0A0R0JIE5_SOYBN Queuine tRNA-ribosyltransferase catalytic subunit 1; Found in the gene: LotjaGi1g1v0340000 | 2 | ||
– | Queuine tRNA-ribosyltransferase; TAIR: AT3G26700.1 Protein kinase superfamily protein; Swiss-Prot: sp|Q28HC6|TGT_XENTR Queuine tRNA-ribosyltransferase catalytic subunit 1; TrEMBL-Plants: tr|A0A0R0KCQ4|A0A0R0KCQ4_SOYBN Queuine tRNA-ribosyltransferase catalytic subunit 1; Found in the gene: LotjaGi1g1v0340000 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | TRNA-guanine transglycosylation | 1 | 25.00 |