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IPR000011 is a Ubiquitin/SUMO-activating enzyme E1-like.
<p>The post-translational attachment of ubiquitin ([interpro:IPR000626]) to proteins (ubiquitinylation) alters the function, location or trafficking of a protein, or targets it to the 26S proteasome for degradation [[cite:PUB00015621], [cite:PUB00015619], [cite:PUB00015625]]. Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2, [interpro:IPR000608]), and a ubiquitin ligase (E3, [interpro:IPR000569], [interpro:IPR003613]), which work sequentially in a cascade [[cite:PUB00015620]]. The E1 enzyme is responsible for activating ubiquitin, the first step in ubiquitinylation. The E1 enzyme hydrolyses ATP and adenylates the C-terminal glycine residue of ubiquitin, and then links this residue to the active site cysteine of E1, yielding a ubiquitin-thioester and free AMP. To be fully active, E1 must non-covalently bind to and adenylate a second ubiquitin molecule. The E1 enzyme can then transfer the thioester-linked ubiquitin molecule to a cysteine residue on the ubiquitin-conjugating enzyme, E2, in an ATP-dependent reaction.</p> <p>This entry includes Ubiquitin-activating enzyme E1 (Uba1), SUMO-activating enzyme subunit 1 (Sae1) and similar proteins from eukaryotes.</p> <p>Sae1 is an heterodimer that acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4 and mediates ATP-dependent activation of SUMO proteins [[cite:PUB00058677], [cite:PUB00038452], [cite:PUB00063223]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Cellular protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). | ||
| Molecular function | Ubiquitin-like modifier activating enzyme activity | Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ubiquitin-activating enzyme E1 1-like [Glycine max] gi|356565998|ref|XP_003551222.1| | 32 | ||
| – | PREDICTED: ubiquitin-activating enzyme E1 1-like isoform X1 [Cicer arietinum] gi|502096113|ref|XP_004490630.1| | 24 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp|P93028|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr|K7KA83|K7KA83_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0116200 | 39 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT5G06460.1 ubiquitin activating enzyme 2; Swiss-Prot: sp|P92974|UBE12_ARATH Ubiquitin-activating enzyme E1 2; TrEMBL-Plants: tr|G7KEA9|G7KEA9_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200 | 39 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp|P93028|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr|G7KEA8|G7KEA8_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200 | 38 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp|P93028|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr|G7KEA8|G7KEA8_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200 | 38 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp|P93028|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr|G7KEA8|G7KEA8_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200 | 38 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp|P93028|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr|G7KEA9|G7KEA9_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200 | 39 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp|P93028|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr|A0A0L9VCA7|A0A0L9VCA7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0126000 | 36 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp|P93028|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr|I1MZW3|I1MZW3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0126000 | 35 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp|P93028|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr|A0A0L9VCA7|A0A0L9VCA7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0126000 | 36 | ||
| – | Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp|P93028|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr|I1MZW3|I1MZW3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0126000 | 35 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01491 | CDD | 1 | 8.33 |