Domain Predictions — View

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IPR018074

Source: InterPro

Description

IPR018074 is a Ubiquitin-activating enzyme E1, conserved site.

Ubiquitin-activating enzyme (E1 enzyme) [[cite:PUB00000623], [cite:PUB00005373]] activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP. Later the ubiquitin moiety is transferred to a cysteine residue on one of the many forms of ubiquitin- conjugating enzymes (E2). E1 is a large monomeric protein of about 110 to 115 Kd (about 1000 residues). In yeast there are two forms (UBA1 and UBA2) [[cite:PUB00002915]], while in plants and mammals multiple forms exist including a form which is Y-linked in mouse and some other mammals and which may be involved in spermatogenesis. It has been shown that the last of the five cysteines that are conserved in the sequence of E1 from various species is the one that binds ubiquitin [[cite:PUB00002725]]. This entry represents a conserved region containing the second of the five conserved cysteines.

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 13

Transcript	Name	Description	Predicted domains	Domain count
Lj0g3v0335099.1 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	PREDICTED: ubiquitin-activating enzyme E1 1-like [Glycine max] gi\|356565998\|ref\|XP_003551222.1\|	Domains G3DSA:1.10.3240.10 G3DSA:3.40.50.720 IPR000011 IPR000594 IPR016040 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 NON_CYTOPLASMIC_DOMAIN PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF164 SIGNAL_PEPTIDE SIGNAL_PEPTIDE_C_REGION SIGNAL_PEPTIDE_H_REGION SIGNAL_PEPTIDE_N_REGION SM00985 SSF69572 TIGR01408 cd01490 cd01491	32
Lj2g3v2315140.1 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	PREDICTED: ubiquitin-activating enzyme E1 1-like isoform X1 [Cicer arietinum] gi\|502096113\|ref\|XP_004490630.1\|	Domains G3DSA:1.10.3240.10 G3DSA:3.40.50.720 IPR000011 IPR000594 IPR016040 IPR018074 IPR018075 IPR019572 IPR032418 IPR032420 IPR033127 PF00899 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF164 SSF69572 TIGR01408 cd01491 mobidb-lite	24
Lj2g3v2315140.2 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	PREDICTED: ubiquitin-activating enzyme E1 1-like isoform X2 [Cicer arietinum] gi\|502096116\|ref\|XP_004490631.1\|	Domains G3DSA:1.10.3240.10 G3DSA:3.40.50.720 IPR000594 IPR016040 IPR018074 IPR018075 IPR019572 IPR032418 IPR032420 IPR033127 PF00899 PF10585 PF16190 PF16191 PS00536 PS00865 PTHR10953 PTHR10953:SF164 SSF69572 TIGR01408	20
LotjaGi1g1v0116200.1 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp\|P93028\|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr\|K7KA83\|K7KA83_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0116200	Domains CYTOPLASMIC_DOMAIN G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 NON_CYTOPLASMIC_DOMAIN PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 TRANSMEMBRANE cd01490 cd01491 mobidb-lite	39
LotjaGi1g1v0116200.2 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT5G06460.1 ubiquitin activating enzyme 2; Swiss-Prot: sp\|P92974\|UBE12_ARATH Ubiquitin-activating enzyme E1 2; TrEMBL-Plants: tr\|G7KEA9\|G7KEA9_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200	Domains CYTOPLASMIC_DOMAIN G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 NON_CYTOPLASMIC_DOMAIN PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 TRANSMEMBRANE cd01490 cd01491 mobidb-lite	39
LotjaGi1g1v0116200.3 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp\|P93028\|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr\|G7KEA8\|G7KEA8_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200	Domains CYTOPLASMIC_DOMAIN G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 NON_CYTOPLASMIC_DOMAIN PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 TRANSMEMBRANE cd01490 cd01491	38
LotjaGi1g1v0116200.4 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp\|P93028\|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr\|G7KEA8\|G7KEA8_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200	Domains CYTOPLASMIC_DOMAIN G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 NON_CYTOPLASMIC_DOMAIN PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 TRANSMEMBRANE cd01490 cd01491	38
LotjaGi1g1v0116200.5 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp\|P93028\|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr\|G7KEA8\|G7KEA8_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200	Domains CYTOPLASMIC_DOMAIN G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 NON_CYTOPLASMIC_DOMAIN PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 TRANSMEMBRANE cd01490 cd01491	38
LotjaGi1g1v0116200.6 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp\|P93028\|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr\|G7KEA9\|G7KEA9_MEDTR Ubiquitin-activating enzyme E1 1; Found in the gene: LotjaGi1g1v0116200	Domains CYTOPLASMIC_DOMAIN G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 NON_CYTOPLASMIC_DOMAIN PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 TRANSMEMBRANE cd01490 cd01491 mobidb-lite	39
LotjaGi6g1v0126000.1 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp\|P93028\|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr\|A0A0L9VCA7\|A0A0L9VCA7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0126000	Domains G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 cd01490 cd01491 mobidb-lite	36
LotjaGi6g1v0126000.2 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp\|P93028\|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr\|I1MZW3\|I1MZW3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0126000	Domains G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 cd01490 cd01491	35
LotjaGi6g1v0126000.3 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp\|P93028\|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr\|A0A0L9VCA7\|A0A0L9VCA7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0126000	Domains G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 cd01490 cd01491 mobidb-lite	36
LotjaGi6g1v0126000.4 View transcript LORE1 v3.0 Genome browser Expression Atlas (ExpAt)	–	Ubiquitin activating enzyme E1; TAIR: AT2G30110.1 ubiquitin-activating enzyme 1; Swiss-Prot: sp\|P93028\|UBE11_ARATH Ubiquitin-activating enzyme E1 1; TrEMBL-Plants: tr\|I1MZW3\|I1MZW3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0126000	Domains G3DSA:1.10.10.2660 G3DSA:2.40.30.180 G3DSA:3.10.290.60 G3DSA:3.40.50.12550 G3DSA:3.40.50.720 G3DSA:3.50.50.80 IPR000011 IPR000594 IPR018074 IPR018075 IPR018965 IPR019572 IPR032418 IPR032420 IPR033127 IPR035985 IPR038252 IPR042063 IPR042302 IPR042449 PF00899 PF09358 PF10585 PF16190 PF16191 PR01849 PS00536 PS00865 PTHR10953 PTHR10953:SF207 SM00985 SSF69572 TIGR01408 cd01490 cd01491	35

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain	Source	Observations	Saturation (%)
cd01491	CDD	1	7.69