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IPR000262 is a FMN-dependent dehydrogenase.
<p>A number of oxidoreductases that act on alpha-hydroxy acids and which are FMN-containing flavoproteins have been shown [[cite:PUB00002617], [cite:PUB00000334], [cite:PUB00002664]] to be structurally related. These enzymes are:</p> <ul> <li>Lactate dehydrogenase ([ec:1.1.2.3]), which consists of a dehydrogenase domain and a haem-binding domain called cytochrome b2 and which catalyses the conversion of lactate into pyruvate.</li> <li>Glycolate oxidase ([ec:1.1.3.15]) ((S)-2-hydroxy-acid oxidase), a peroxisomal enzyme that catalyses the conversion of glycolate and oxygen to glyoxylate and hydrogen peroxide.</li> <li>Long chain alpha-hydroxy acid oxidase from rat ([ec:1.1.3.15]), a peroxisomal enzyme.</li> <li>Lactate 2-monooxygenase ([ec:1.13.12.4]) (lactate oxidase) from Mycobacterium smegmatis, which catalyses the conversion of lactate and oxygen to acetate, carbon dioxide and water.</li> <li>(S)-mandelate dehydrogenase from Pseudomonas putida (gene mdlB), which catalyses the reduction of (S)-mandelate to benzoylformate.</li></ul> <p>The first step in the reaction mechanism of these enzymes is the abstraction of the proton from the α-carbon of the substrate producing a carbanion which can subsequently attach to the N5 atom of FMN. A conserved histidine has been shown [[cite:PUB00002533]] to be involved in the removal of the proton. The region around this active site residue is highly conserved and contains an arginine residue which is involved in substrate binding.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase GLO1-like [Cucumis sativus] gi|449526029|ref|XP_004170017.1| | 10 | ||
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase-like isoform X1 [Cicer arietinum] gi|502087985|ref|XP_004488698.1| | 13 | ||
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase GLO1-like [Cicer arietinum] gi|502141606|ref|XP_004504562.1| | 13 | ||
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase GLO1-like [Cicer arietinum] gi|502141606|ref|XP_004504562.1| | 12 | ||
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase GLO1 [Glycine max] gi|356525084|ref|XP_003531157.1| | 12 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3SHL4|I3SHL4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0145600 | 14 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.5 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3SHL4|I3SHL4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0145600 | 14 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 15 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 15 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 15 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 15 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT4G18360.2 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|O49506|GLO5_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO5; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02809 | CDD | 1 | 8.33 |