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IPR012133 is a Alpha-hydroxy acid dehydrogenase, FMN-dependent.
<p>This group represents alpha-hydroxy acid FMN-dependent dehydrogenases, including human glycolate oxidase (GO), L-lactate oxidase (LOX) [[cite:PUB00043804]] and bacterial L-lactate dehydrogenase. GO catalyses the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate. The latter is a key metabolite in kidney stone formation. 4-carboxy-5-dodecylsulphanyl-1,2,3-triazole (CDST) is an inhibitor of this enzyme. In contrast to most alpha-hydroxy acid oxidases, including spinach glycolate oxidase, a loop region, known as loop 4, is completely visible when the GO active site contains a small ligand. Since this is an unique structural feature, it has the potential to be a target for drugs to decrease glycolate and glyoxylate levels in primary hyperoxaluria type 1 patients who have the inability to convert peroxisomal glyoxylate to glycine [[cite:PUB00043803]].</p> <p>This entry also includes the fungal protein FUB9 by virtue of sequence similarity to the FMN-dependent alpha-hydroxy acid dehydrogenase family. FUB9 is an oxidase that is part of the gene cluster that mediates the biosynthesis of fusaric acid [[cite:PUB00082314]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | FMN binding | Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. | ||
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase GLO1-like [Cucumis sativus] gi|449526029|ref|XP_004170017.1| | 10 | ||
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase-like isoform X1 [Cicer arietinum] gi|502087985|ref|XP_004488698.1| | 13 | ||
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase GLO1-like [Cicer arietinum] gi|502141606|ref|XP_004504562.1| | 13 | ||
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase GLO1-like [Cicer arietinum] gi|502141606|ref|XP_004504562.1| | 12 | ||
| – | PREDICTED: peroxisomal (S)-2-hydroxy-acid oxidase GLO1 [Glycine max] gi|356525084|ref|XP_003531157.1| | 12 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3SHL4|I3SHL4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0145600 | 14 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.5 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3SHL4|I3SHL4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0145600 | 14 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 15 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 15 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 15 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT3G14420.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|Q9LRR9|GLO1_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 15 | ||
| – | Peroxisomal (S)-2-hydroxy-acid oxidase; TAIR: AT4G18360.2 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|O49506|GLO5_ARATH Peroxisomal (S)-2-hydroxy-acid oxidase GLO5; TrEMBL-Plants: tr|I3S358|I3S358_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360300 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02809 | CDD | 1 | 8.33 |