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IPR000652 is a Triosephosphate isomerase.
<p>Triosephosphate isomerase ([ec:5.3.1.1]) (TIM) [[cite:PUB00000326]] is the glycolytic enzyme that catalyses the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, highly conserved in prokaryotes and eukaryotes. In pathogenic organisms, this enzyme plays a crucial role obtaining energy for infection and survival. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism [[cite:PUB00004091], [cite:PUB00029041], [cite:PUB00099868]].</p> <p>The tertiary structure of TIM has eight β/α motifs folded into a barrel structure. The TIM barrel fold occurs ubiquitously and is found in numerous other enzymes that can be involved in energy metabolism, macromolecule metabolism, or small molecule metabolism [[cite:PUB00027646]].</p> <p>The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder [[cite:PUB00014239]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Triose-phosphate isomerase activity | Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Triosephosphate isomerase [Glycine max] gi|77540216|gb|ABA86966.1| | 14 | ||
| – | PREDICTED: triosephosphate isomerase, cytosolic-like [Cicer arietinum] gi|502081910|ref|XP_004487007.1| | 14 | ||
| – | PREDICTED: triosephosphate isomerase, chloroplastic-like [Cicer arietinum] gi|502111535|ref|XP_004494086.1| | 15 | ||
| – | Triosephosphate isomerase; TAIR: AT2G21170.1 triosephosphate isomerase; Swiss-Prot: sp|Q9M4S8|TPIC_FRAAN Triosephosphate isomerase, chloroplastic; TrEMBL-Plants: tr|I3SZG4|I3SZG4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0686000 | 16 | ||
| – | Triosephosphate isomerase; TAIR: AT3G55440.1 triosephosphate isomerase; Swiss-Prot: sp|P48491|TPIS_ARATH Triosephosphate isomerase, cytosolic; TrEMBL-Plants: tr|I3SUT5|I3SUT5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0283700 | 15 | ||
| – | Triosephosphate isomerase; TAIR: AT3G55440.1 triosephosphate isomerase; Swiss-Prot: sp|P21820|TPIS_COPJA Triosephosphate isomerase, cytosolic; TrEMBL-Plants: tr|I3SUT5|I3SUT5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0283700 | 13 | ||
| – | Triosephosphate isomerase; TAIR: AT3G55440.1 triosephosphate isomerase; Swiss-Prot: sp|P21820|TPIS_COPJA Triosephosphate isomerase, cytosolic; TrEMBL-Plants: tr|I3SUT5|I3SUT5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0283700 | 13 | ||
| – | Triosephosphate isomerase; TAIR: AT3G55440.1 triosephosphate isomerase; Swiss-Prot: sp|P48495|TPIS_PETHY Triosephosphate isomerase, cytosolic; TrEMBL-Plants: tr|I3SUT5|I3SUT5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0401100 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00311 | CDD | 1 | 12.50 |