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IPR000846 is a Dihydrodipicolinate reductase, N-terminal.
<p>Dihydrodipicolinate reductase catalyzes the second step in the biosynthesis of diaminopimelic acid and lysine, the NAD or NADP-dependent reduction of 2,3-dihydrodipicolinate into 2,3,4,5-tetrahydrodipicolinate [[cite:PUB00019387], [cite:PUB00019388], [cite:PUB00000417]].</p> <p>In Escherichia coli and Mycobacterium tuberculosis, dihydrodipicolinate reductase has equal specificity for NADH and NADPH, however in Thermotoga maritima there it has a greater affinity for NADPH [[cite:PUB00043321]]. In addition, the enzyme is inhibited by high concentrations of its substrate, which consequently acts as a feedback control on the lysine biosynthesis pathway. In T. maritima, the enzyme also lacks N-terminal and C-terminal loops which are present in enzyme of the former two organisms.</p> <p>This entry represents the N-terminal domain of dihydrodipicolinate reductase which binds the dinucleotide NAD(P)H.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 4-hydroxy-tetrahydrodipicolinate reductase | Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+. | ||
| Biological process | Lysine biosynthetic process via diaminopimelate | The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Dihydrodipicolinate reductase [Medicago truncatula] gi|357444055|ref|XP_003592305.1| | 14 | ||
| – | Dihydrodipicolinate reductase [Medicago truncatula] gi|357444055|ref|XP_003592305.1| | 14 | ||
| – | Dihydrodipicolinate reductase [Medicago truncatula] gi|357444057|ref|XP_003592306.1| | 8 | ||
| – | 4-hydroxy-tetrahydrodipicolinate reductase; TAIR: AT3G59890.1 Dihydrodipicolinate reductase, bacterial/plant; Swiss-Prot: sp|Q8LB01|DAPB2_ARATH 4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q308|A0A0B2Q308_GLYSO Dihydrodipicolinate reductase 2, chloroplastic; Found in the gene: LotjaGi3g1v0390800 | 13 | ||
| – | 4-hydroxy-tetrahydrodipicolinate reductase; TAIR: AT5G52100.1 Dihydrodipicolinate reductase, bacterial/plant; Swiss-Prot: sp|Q9FJ82|DAPB3_ARATH Dihydrodipicolinate reductase-like protein CRR1, chloroplastic; TrEMBL-Plants: tr|A0A151U6L0|A0A151U6L0_CAJCA Uncharacterized protein; Found in the gene: LotjaGi5g1v0304200 | 13 | ||
| – | 4-hydroxy-tetrahydrodipicolinate reductase; TAIR: AT5G52100.1 Dihydrodipicolinate reductase, bacterial/plant; Swiss-Prot: sp|Q9FJ82|DAPB3_ARATH Dihydrodipicolinate reductase-like protein CRR1, chloroplastic; TrEMBL-Plants: tr|K7N3N1|K7N3N1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0304200 | 13 | ||
| – | 4-hydroxy-tetrahydrodipicolinate reductase; TAIR: AT5G52100.1 Dihydrodipicolinate reductase, bacterial/plant; Swiss-Prot: sp|Q9FJ82|DAPB3_ARATH Dihydrodipicolinate reductase-like protein CRR1, chloroplastic; TrEMBL-Plants: tr|I1NGQ2|I1NGQ2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0304200 | 13 | ||
| – | 4-hydroxy-tetrahydrodipicolinate reductase; TAIR: AT5G52100.1 Dihydrodipicolinate reductase, bacterial/plant; Swiss-Prot: sp|Q9FJ82|DAPB3_ARATH Dihydrodipicolinate reductase-like protein CRR1, chloroplastic; TrEMBL-Plants: tr|K7N3N1|K7N3N1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0304200 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF55347 | SUPERFAMILY | 1 | 12.50 |