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IPR011859 is a Dihydrodipicolinate reductase, plant-type.
<p>Dihydrodipicolinate reductase is an enzyme found in bacteria and higher plants which is involved in the biosynthesis of diaminopimelic acid, a component of bacterial cell walls, and the essential amino acid L-lysine. It catalyses the the reduced pyridine nucleotide-dependent reduction of the alpha,beta-unsaturated cyclic imine, dihydrodipicolinate, to generate tetrahydrodipicolinate as shown below [[cite:PUB00028085]]: <reaction>2,3-dihydrodipicolinate + NAD(P)H = 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+)</reaction> As this enzyme is not found in mammals it is a potential target for the development of novel antibacterial and herbicidal compounds.</p> <p>This narrow family includes genes from Arabidopsis and Fibrobacter succinogenes (Bacteroides succinogenes) (which probably recieved the gene from a plant via lateral gene transfer). The sequences are distantly related to the dihydrodipicolinate reductases from archaea. In Fibrobacter this gene is the only candidate DHPR in the genome.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 4-hydroxy-tetrahydrodipicolinate reductase | Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+. | ||
| Biological process | Lysine biosynthetic process via diaminopimelate | The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. | ||
| Molecular function | NADPH binding | Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | 4-hydroxy-tetrahydrodipicolinate reductase; TAIR: AT3G59890.1 Dihydrodipicolinate reductase, bacterial/plant; Swiss-Prot: sp|Q8LB01|DAPB2_ARATH 4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic; TrEMBL-Plants: tr|A0A0B2Q308|A0A0B2Q308_GLYSO Dihydrodipicolinate reductase 2, chloroplastic; Found in the gene: LotjaGi3g1v0390800 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR02130 | TIGRFAM | 1 | 100.00 |