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IPR001193 is a Membrane-bound transcription factor site-2 protease.
<p>This entry represents the membrane-bound transcription factor site-2 protease (MBTPS2, also known as S2P) [[cite:PUB00067929]].</p> <p>MBTPS2 is a membrane-embedded zinc metalloprotease that activates signaling proteins involved in sterol control of transcription and ER stress response [[cite:PUB00067929]]. It cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Its known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6 [[cite:PUB00003639], [cite:PUB00067931]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. | ||
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. | ||
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: membrane-bound transcription factor site-2 protease-like [Glycine max] gi|356560965|ref|XP_003548756.1| | 13 | ||
| – | PREDICTED: membrane-bound transcription factor site-2 protease-like [Glycine max] gi|356560965|ref|XP_003548756.1| | 10 | ||
| – | Protease m50 membrane-bound transcription factor site 2 protease, putative; TAIR: AT4G20310.4 Peptidase M50 family protein; Swiss-Prot: sp|F4JUU5|S2P_ARATH Membrane-bound transcription factor site-2 protease homolog; TrEMBL-Plants: tr|A0A0B2Q9W2|A0A0B2Q9W2_GLYSO Membrane-bound transcription factor site-2 protease; Found in the gene: LotjaGi4g1v0149600 | 11 | ||
| – | Protease m50 membrane-bound transcription factor site 2 protease, putative; TAIR: AT4G20310.4 Peptidase M50 family protein; Swiss-Prot: sp|F4JUU5|S2P_ARATH Membrane-bound transcription factor site-2 protease homolog; TrEMBL-Plants: tr|A0A0B2Q9W2|A0A0B2Q9W2_GLYSO Membrane-bound transcription factor site-2 protease; Found in the gene: LotjaGi4g1v0149600 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 25.00 |