Description

IPR001304 is a C-type lectin-like.

<p>A number of different families of proteins share a conserved domain which was first characterised in some animal lectins and which seem to function as a calcium-dependent carbohydrate-recognition domain [[cite:PUB00002490], [cite:PUB00004941]]. This domain, which is known as the C-type lectin domain (CTL) or as the carbohydrate-recognition domain (CRD), consists of about 110 to 130 residues. There are four cysteines which are perfectly conserved and involved in two disulphide bonds.</p> <p>There are proteins with modules similar in overall structure to CRDs that serve functions other than sugar binding. Therefore, a more general term C-type lectin-like domain was introduced to refer to such domains, although both terms C-type lectin and C-type lectin-like are sometimes used interchangeably [[cite:PUB00081335]].</p> <p>C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [[cite:PUB00042644]]. Lectins are a diverse group of proteins, both in terms of structure and activity. Carbohydrate binding ability may have evolved independently and sporadically in numerous unrelated families, where each evolved a structure that was conserved to fulfil some other activity and function. In general, animal lectins act as recognition molecules within the immune system, their functions involving defence against pathogens, cell trafficking, immune regulation and the prevention of autoimmunity [[cite:PUB00042645]].</p> <p>This entry also includes alpha-type phospholipase A2 inhibitors (PLI-alpha), a group of proteins that have been found in a number of Viperidae snakes [[cite:PUB00042882], [cite:PUB00103664]]. Most PLI-alpha proteins are homomultimers composed of 3-5 subunits, except in Trimeresurus flavoviridis (Habu), where PLI-alpha consists of a trimer of two homologous subunits (PLI-alpha-A and PLI-alpha-B), each of which contains one C-type lectin-like domain and exhibiting significant homology to serum mannose-binding protein and lung-surfactant apoprotein [[cite:PUB00042881]]. A PLI-alpha homologue that lacks inhibitory activity was found in the non-venomous snake Elaphe quadrivirgata (Japanese four-lined ratsnake) [[cite:PUB00042883]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: