Description

IPR016186 is a C-type lectin-like/link domain superfamily.

<p>Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity [[cite:PUB00042634]], they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions [[cite:PUB00042635]]. There are at least twelve structural families of lectins, of which C-type (Ca+-dependent) lectins is one. C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [[cite:PUB00042644]].</p> <p>The term 'C-type lectin domain' was introduced to distinguish a carbohydrate-recognition domain (CRD) which is present in all Ca2+-dependent lectins, but not in other types of animal lectins. However, there are proteins with modules similar in overall structure to CRDs that serve functions other than sugar binding. Therefore, a more general term C-type lectin-like domain was introduced to refer to such domains, although both terms are sometimes used interchangeably [[cite:PUB00081335]].</p> <p>This superfamily represents a structural domain found in C-type lectins, as well as in other proteins, including:</p> <ul> <li>The C-terminal domain of invasin [[cite:PUB00018560]] and intimin [[cite:PUB00006623]].</li> <li>Link domain, which includes the Link module of tumor necrosis factor-inducible gene 6 protein (TSG-6) [[cite:PUB00022318]] (a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal β-strand and C-terminal β-hairpin) [[cite:PUB00022805]]. The Link domain may have emerged as a result of a deletion of the long loop region from an ancestral canonical C-type lectin domain [[cite:PUB00001702]].</li> <li>Endostatin [[cite:PUB00021244]] and the endostatin domain of collagen alpha 1 (XV) [[cite:PUB00024352]], these domains being decorated with many insertions in the common fold.</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: