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IPR001466 is a Beta-lactamase-related.
<p>This entry represents the serine beta-lactamase-like superfamily. It is a group of diverse group of sequences that includes D-alanyl-D-alanine carboxypeptidase B, aminopeptidase (DmpB), alkaline D-peptidase, animal D-Ala-D-Ala carboxypeptidase homologues and the class A and C beta-lactamases and eukaryotic beta-lactamase homologues which are variously described as: transesterases, non-ribosomal peptide synthetases and hypothetical proteins. Many are serine peptidases belonging to MEROPS peptidase families S11 (D-Ala-D-Ala carboxypeptidase A family) and S12 (D-Ala-D-Ala carboxypeptidase B family, clan SE). The beta-lactamases are classified as both S11 and S12 non-peptidase homologues; these either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for the catalytic activity.</p> <p>Beta-lactamase catalyses the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins [[cite:PUB00003270]]. There are four groups, classed A, B, C and D according to sequence, substrate specificity, and kinetic behaviour: class A (penicillinase-type) is the most common [[cite:PUB00003270]]. The genes for class A beta-lactamases are widely distributed in bacteria, frequently located on transmissible plasmids in Gram-negative organisms, although an equivalent chromosomal gene has been found in a few species [[cite:PUB00000477]].</p> <p>Class A, C and D beta-lactamases are serine-utilising hydrolases - class B enzymes utilise a catalytic zinc centre instead. The 3 classes of serine beta-lactamase are evolutionarily related and belong to a superfamily that also includes DD-peptidases and other penicillin-binding proteins [[cite:PUB00000464]]. All these proteins contain an S-x-x-K motif, the Ser being the active site residue. Although clearly related, however, the sequences of the 3 classes of serine beta-lactamases vary considerably outside the active site.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | ABC1 family protein [Arabidopsis lyrata subsp]. lyrata] gi|297812683|ref|XP_002874225.1| | 6 | ||
| – | ABC1 protein kinase; TAIR: AT5G24810.1 ABC1 family protein; Swiss-Prot: sp|P73627|Y1770_SYNY3 Uncharacterized protein sll1770; TrEMBL-Plants: tr|A0A0S3RN26|A0A0S3RN26_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0198800 | 15 | ||
| – | ABC1 protein kinase; TAIR: AT5G24810.1 ABC1 family protein; Swiss-Prot: sp|P73627|Y1770_SYNY3 Uncharacterized protein sll1770; TrEMBL-Plants: tr|A0A0S3RN26|A0A0S3RN26_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0198800 | 15 | ||
| – | ABC1 protein kinase; TAIR: AT5G24810.1 ABC1 family protein; Swiss-Prot: sp|Q09621|LACT2_CAEEL Beta-lactamase domain-containing protein 2; TrEMBL-Plants: tr|A0A0S3RN26|A0A0S3RN26_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0198800 | 13 | ||
| – | ABC1 protein kinase; TAIR: AT5G24810.1 ABC1 family protein; Swiss-Prot: sp|P73627|Y1770_SYNY3 Uncharacterized protein sll1770; TrEMBL-Plants: tr|A0A0S3RN26|A0A0S3RN26_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0198800 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |