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IPR001468 is a Indole-3-glycerol phosphate synthase, conserved site.
<p>Indole-3-glycerol phosphate synthase ([ec:4.1.1.48]) (IGPS) catalyses the fourth step in the biosynthesis of tryptophan, the ring closure of 1-(2-carboxy-phenylamino)-1-deoxyribulose into indol-3-glycerol-phosphate. In some bacteria, IGPS is a single chain enzyme. In others, such as Escherichia coli, it is the N-terminal domain of a bifunctional enzyme that also catalyses N-(5'-phosphoribosyl)anthranilate isomerase ([ec:5.3.1.24]) (PRAI) activity (see [interpro:IPR001240]), the third step of tryptophan biosynthesis. In fungi, IGPS is the central domain of a trifunctional enzyme that contains a PRAI C-terminal domain and a glutamine amidotransferase ([ec:2.4.2]) (GATase) N-terminal domain.</p> <p>A structure of the IGPS domain of the bifunctional enzyme from the mesophilic bacterium E. coli (eIGPS) has been compared with the monomeric indole-3-glycerol phosphate synthase from the hyperthermophilic archaeon Sulfolobus solfataricus (sIGPS). Both are single-domain (β/α)8 barrel proteins, with one (eIGPS) or two (sIGPS) additional helices inserted before the first β strand [[cite:PUB00007146]].</p> <p>This entry represents a highly conserved region within the N-terminal section of IGPS, which has been shown to be part of the active site cavity.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Indole-3-glycerol-phosphate synthase activity | Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. | ||
| Biological process | Tryptophan metabolic process | The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Indole-3-glycerol phosphate synthase [Medicago truncatula] gi|357492951|ref|XP_003616764.1| | 12 | ||
| – | Indole-3-glycerol phosphate synthase; TAIR: AT5G48220.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|P49572|TRPC_ARATH Indole-3-glycerol phosphate synthase, chloroplastic; TrEMBL-Plants: tr|G7KH34|G7KH34_MEDTR Indole-3-glycerol phosphate synthase; Found in the gene: LotjaGi1g1v0070800 | 12 | ||
| – | Indole-3-glycerol phosphate synthase; TAIR: AT5G48220.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|P49572|TRPC_ARATH Indole-3-glycerol phosphate synthase, chloroplastic; TrEMBL-Plants: tr|A0A072UF41|A0A072UF41_MEDTR Indole-3-glycerol phosphate synthase; Found in the gene: LotjaGi1g1v0070800 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |