Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR001486 is a Truncated hemoglobin.
<p>This entry represents a group of haemoglobin-like proteins found in eubacteria, cyanobacteria, protozoa, algae and plants, but not in animals or yeast. These proteins have a truncated 2-over-2 rather than the canonical 3-over-3 α-helical sandwich fold [[cite:PUB00035871]]. They include:</p> <ul> <li>HbN (or GlbN): a truncated haemoglobin-like protein that binds oxygen cooperatively with a very high affinity and a slow dissociation rate, which may exclude it from oxygen transport. It appears to be involved in bacterial nitric oxide detoxification and in nitrosative stress [[cite:PUB00035878]].</li> <li>Cyanoglobin (or GlbN): a truncated haemoprotein found in cyanobacteria that has high oxygen affinity, and which appears to serve as part of a terminal oxidase, rather than as a respiratory pigment [[cite:PUB00035880]].</li> <li>HbO (or GlbO): a truncated haemoglobin-like protein with a lower oxygen affinity than HbN. HbO associates with the bacterial cell membrane, where it significantly increases oxygen uptake over membranes lacking this protein. HbO appears to interact with a terminal oxidase, and could participate in an oxygen/electron-transfer process that facilitates oxygen transfer during aerobic metabolism [[cite:PUB00035879]].</li> <li>Glb3: a nuclear-encoded truncated haemoglobin from plants that appears more closely related to HbO than HbN. Glb3 from Arabidopsis thaliana (Mouse-ear cress) exhibits an unusual concentration-independent binding of oxygen and carbon dioxide [[cite:PUB00035881]].</li> </ul> <p>The truncated haemoglobin (trHb) family branches into three main groups, designated as type I, II and III and named as HbN, HbO and HbP, respectively. The trHbO gene (also known as glbO) has been predicted as the ancestral gene, with group I and group III genes appearing as a result of duplication and transfer events. There is an accumulating evidence suggests that trHbs may be implicated in functions other than oxygen delivery [[cite:PUB00153745]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxygen binding | Interacting selectively and non-covalently with oxygen (O2). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: group 2 truncated hemoglobin YjbI-like [Cicer arietinum] gi|502124477|ref|XP_004498545.1| | 8 | ||
| – | PREDICTED: group 2 truncated hemoglobin YjbI-like [Cicer arietinum] gi|502124477|ref|XP_004498545.1| | 8 | ||
| – | PREDICTED: group 2 truncated hemoglobin YjbI-like [Cicer arietinum] gi|502124477|ref|XP_004498545.1| | 8 | ||
| – | Hemoglobin-like protein; TAIR: AT4G32690.1 hemoglobin 3; Swiss-Prot: sp|Q67XG0|GLB3_ARATH Two-on-two hemoglobin-3; TrEMBL-Plants: tr|I3SAV1|I3SAV1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0172000 | 8 | ||
| – | Hemoglobin-like protein; TAIR: AT4G32690.1 hemoglobin 3; Swiss-Prot: sp|Q67XG0|GLB3_ARATH Two-on-two hemoglobin-3; TrEMBL-Plants: tr|A0A0L9TDT4|A0A0L9TDT4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0398700 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd08917 | CDD | 1 | 20.00 |