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IPR001805

Source: InterPro

Description

IPR001805 is a Adenosine kinase.

<p>Adenosine kinase (ADK) phosphorylates adenosine and other related nucleosides [[cite:PUB00004876], [cite:PUB00001470]]. It is exclusive to eukaryotes [[cite:PUB00000259]] and is a key enzyme in the purine salvage pathway. ADK catalyses the reaction:</p> <reaction>Adenosine + ATP = ADP + AMP</reaction> <p>This reaction prevents toxic levels of adenosine building up within the cell. Experiments have been carried out on Gallus gallus (chicken) embryonic neurons to document the toxicity of adenosine, and the associated requirement for ADK [[cite:PUB00004319]].</p> <p>Adenosine and ATP have been connected with pain, and the control of pain [[cite:PUB00001483]]. Associated with this, adenosine has also been shown to have a number of anti-inflammatory activities. Human ADK bears little sequence similarity to other mammalian nucleoside kinases, but does share high similarity with some microbrial ribokinases and fructokinases, suggesting possible evolutionary connections [[cite:PUB00004876], [cite:PUB00001470]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004001
Molecular function Adenosine kinase activity Catalysis of the reaction: ATP + adenosine = ADP + AMP.
Subterm of
GO:0006166
Biological process Purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj5g3v0659730.1
– Adenosine kinase [Theobroma cacao] gi|95116510|gb|ABF56168.1|
Domains
12
Lj5g3v0659730.2
– PREDICTED: adenosine kinase 2-like [Cicer arietinum] gi|502121977|ref|XP_004497518.1|
Domains
13
Lj5g3v0659730.3
– Adenosine kinase [Medicago truncatula] gi|357440381|ref|XP_003590468.1|
Domains
10
LotjaGi1g1v0689800.1
– Adenosine kinase, putative; TAIR: AT5G03300.1 adenosine kinase 2; Swiss-Prot: sp|Q9LZG0|ADK2_ARATH Adenosine kinase 2; TrEMBL-Plants: tr|A0A0B2P3T7|A0A0B2P3T7_GLYSO Adenosine kinase 2; Found in the gene: LotjaGi1g1v0689800
Domains
12
LotjaGi5g1v0080200.1
– Adenosine kinase, putative; TAIR: AT5G03300.1 adenosine kinase 2; Swiss-Prot: sp|Q9LZG0|ADK2_ARATH Adenosine kinase 2; TrEMBL-Plants: tr|I3SE78|I3SE78_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0080200
Domains
13
LotjaGi5g1v0080200.2
– Adenosine kinase, putative; TAIR: AT5G03300.1 adenosine kinase 2; Swiss-Prot: sp|Q9LZG0|ADK2_ARATH Adenosine kinase 2; TrEMBL-Plants: tr|I3SE78|I3SE78_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0080200
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01168 CDD 1 16.67