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IPR001949 is a NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site.
<p>NADH:ubiquinone oxidoreductase (complex I) ([ec:7.1.1.2]) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [[cite:PUB00005074]]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [[cite:PUB00043561]], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [[cite:PUB00045437]].</p> <p>Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 51kDa (in mammals), which is the second largest subunit of complex I and is a component of the iron-sulphur (IP) fragment of the enzyme. It seems to bind to NAD, FMN, and a 2Fe-2S cluster. The 51kDa subunit and the bacterial hydrogenase alpha subunit contain three regions of sequence similarities. The first one most probably corresponds to the NAD-binding site, the second to the FMN-binding site, and the third one, which contains three cysteines, to the iron-sulphur binding region.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | NADH dehydrogenase (ubiquinone) activity | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. | ||
| Molecular function | FMN binding | Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. | ||
| Molecular function | 4 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | NADH-quinone oxidoreductase subunit F [Medicago truncatula] gi|357439369|ref|XP_003589961.1| | 17 | ||
| – | NADH oxidoreductase F subunit; TAIR: AT5G08530.1 51 kDa subunit of complex I; Swiss-Prot: sp|Q9FNN5|NDUV1_ARATH NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; TrEMBL-Plants: tr|G7I3R9|G7I3R9_MEDTR NADH-ubiquinone oxidoreductase 51 kDa subunit; Found in the gene: LotjaGi6g1v0004400 | 22 | ||
| – | NADH oxidoreductase F subunit; TAIR: AT5G08530.1 51 kDa subunit of complex I; Swiss-Prot: sp|Q9FNN5|NDUV1_ARATH NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; TrEMBL-Plants: tr|A0A199W8W0|A0A199W8W0_ANACO NADH dehydrogenase (Ubiquinone) flavoprotein 1, mitochondrial; Found in the gene: LotjaGi6g1v0004400 | 24 | ||
| – | NADH oxidoreductase F subunit; TAIR: AT5G08530.1 51 kDa subunit of complex I; Swiss-Prot: sp|Q9FNN5|NDUV1_ARATH NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; TrEMBL-Plants: tr|G7I3R9|G7I3R9_MEDTR NADH-ubiquinone oxidoreductase 51 kDa subunit; Found in the gene: LotjaGi6g1v0004400 | 22 | ||
| – | NADH oxidoreductase F subunit; TAIR: AT5G08530.1 51 kDa subunit of complex I; Swiss-Prot: sp|Q9FNN5|NDUV1_ARATH NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; TrEMBL-Plants: tr|G7I3R9|G7I3R9_MEDTR NADH-ubiquinone oxidoreductase 51 kDa subunit; Found in the gene: LotjaGi6g1v0004400 | 22 | ||
| – | NADH oxidoreductase F subunit; TAIR: AT5G08530.1 51 kDa subunit of complex I; Swiss-Prot: sp|Q9FNN5|NDUV1_ARATH NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; TrEMBL-Plants: tr|G7I3R9|G7I3R9_MEDTR NADH-ubiquinone oxidoreductase 51 kDa subunit; Found in the gene: LotjaGi6g1v0004400 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |