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IPR001958

Source: InterPro

Description

IPR001958 is a Tetracycline resistance protein TetA/multidrug resistance protein MdtG-like.

<p>The tetracycline resistance protein Tet(A) is a tetracycline efflux protein that functions as a metal-tetracycline/H+ antiporter [[cite:PUB00035987], [cite:PUB00035988]]. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. Tet(A) is encoded by the transposon Tn10, and is an integral membrane protein with twelve potential transmembrane domains. Site-directed mutagenesis studies have shown that a negative charge at position 66 is essential for tetracycline transport [[cite:PUB00006063]], and that the region that includes the dipeptide plays an important role in metal-tetracycline transport; it perhaps acts as a gate that opens on the charge-charge interaction between Asp66 and the metal-tetracycline. The histidine at position 257 plays an essential role in H+ translocation [[cite:PUB00070990]].</p> <p>Multidrug resistance protein MdtG is found in enterobacteria and confers resistance to fosfomycin and deoxycholate [[cite:PUB00053912]].</p> <p>Both TetA and MdtG belong to major facilitator superfamily (MFS), the largest and most diverse superfamily of secondary active transporters [[cite:PUB00071559]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0022857
Molecular function Transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
Subterm of

Associated Lotus transcripts 11

Transcript Name Description Predicted domains Domain count
Lj1g3v3690320.1
– PREDICTED: protein ZINC INDUCED FACILITATOR-LIKE 1-like [Cicer arietinum] gi|502180015|ref|XP_004516549.1|
Domains
15
Lj3g3v0797540.1
– PREDICTED: protein ZINC INDUCED FACILITATOR-LIKE 1-like isoform X1 [Cicer arietinum] gi|502174133|ref|XP_004515444.1|
Domains
15
Lj6g3v1052420.1
– PREDICTED: protein ZINC INDUCED FACILITATOR-LIKE 1-like isoform X1 [Cicer arietinum] gi|502180042|ref|XP_004516554.1|
Domains
16
LotjaGi1g1v0613200.1
– Protein ZINC INDUCED FACILITATOR-LIKE 1; TAIR: AT5G13750.1 zinc induced facilitator-like 1; Swiss-Prot: sp|Q94BZ1|ZIFL1_ARATH Protein ZINC INDUCED FACILITATOR-LIKE 1; TrEMBL-Plants: tr|I3SEY1|I3SEY1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0613200
Domains
16
LotjaGi1g1v0614000.1
– Protein ZINC INDUCED FACILITATOR-LIKE 1; TAIR: AT5G13750.1 zinc induced facilitator-like 1; Swiss-Prot: sp|Q94BZ1|ZIFL1_ARATH Protein ZINC INDUCED FACILITATOR-LIKE 1; TrEMBL-Plants: tr|I3SEY1|I3SEY1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0614000
Domains
16
LotjaGi1g1v0614000.2
– Protein ZINC INDUCED FACILITATOR-LIKE 1; TAIR: AT5G13750.1 zinc induced facilitator-like 1; Swiss-Prot: sp|Q94BZ1|ZIFL1_ARATH Protein ZINC INDUCED FACILITATOR-LIKE 1; TrEMBL-Plants: tr|I3SEY1|I3SEY1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0614000
Domains
16
LotjaGi3g1v0101600.1
– Protein ZINC INDUCED FACILITATOR-LIKE 1; TAIR: AT5G13750.1 zinc induced facilitator-like 1; Swiss-Prot: sp|Q94BZ1|ZIFL1_ARATH Protein ZINC INDUCED FACILITATOR-LIKE 1; TrEMBL-Plants: tr|G7IVI0|G7IVI0_MEDTR Zinc induced facilitator-like protein; Found in the gene: LotjaGi3g1v0101600
Domains
16
LotjaGi3g1v0102200.1
– Protein ZINC INDUCED FACILITATOR-LIKE 1; TAIR: AT5G13750.1 zinc induced facilitator-like 1; Swiss-Prot: sp|Q94BZ1|ZIFL1_ARATH Protein ZINC INDUCED FACILITATOR-LIKE 1; TrEMBL-Plants: tr|G7IVI3|G7IVI3_MEDTR Zinc induced facilitator-like protein; Found in the gene: LotjaGi3g1v0102200
Domains
16
LotjaGi3g1v0309300.1
– Protein ZINC INDUCED FACILITATOR-LIKE 1; TAIR: AT5G13750.1 zinc induced facilitator-like 1; Swiss-Prot: sp|Q94BZ1|ZIFL1_ARATH Protein ZINC INDUCED FACILITATOR-LIKE 1; TrEMBL-Plants: tr|A0A072TNX0|A0A072TNX0_MEDTR Zinc induced facilitator-like protein; Found in the gene: LotjaGi3g1v0309300
Domains
16
LotjaGi3g1v0309500.1
– Protein ZINC INDUCED FACILITATOR-LIKE 1; TAIR: AT5G13750.1 zinc induced facilitator-like 1; Swiss-Prot: sp|Q94BZ1|ZIFL1_ARATH Protein ZINC INDUCED FACILITATOR-LIKE 1; TrEMBL-Plants: tr|A0A072TNX0|A0A072TNX0_MEDTR Zinc induced facilitator-like protein; Found in the gene: LotjaGi3g1v0309500
Domains
17
LotjaGi3g1v0309500.2
– Protein ZINC INDUCED FACILITATOR-LIKE 1; TAIR: AT5G13750.1 zinc induced facilitator-like 1; Swiss-Prot: sp|Q94BZ1|ZIFL1_ARATH Protein ZINC INDUCED FACILITATOR-LIKE 1; TrEMBL-Plants: tr|A0A072TNX0|A0A072TNX0_MEDTR Zinc induced facilitator-like protein; Found in the gene: LotjaGi3g1v0309500
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 9.09