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IPR002071

Source: InterPro

Description

IPR002071 is a Thermonuclease active site.

<p>Staphylococcus aureus secretes a thermostable nuclease ([ec:3.1.31.1]), known as thermonuclease (TNase), which is a calcium-dependent enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond yielding 3'-mononucleotides and dinucleotides [[cite:PUB00004982]]. This signature contains the three residues, two arginines and a glutamate, that form the active site. The sequence of the TNase of S. aureus is evolutionary related [[cite:PUB00001847]] to other TNase's of other Staphylococcus spp as well as to several other proteins.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003676
Molecular function Nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
Subterm of
GO:0004518
Molecular function Nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj0g3v0054689.1
– Ca(2+)-dependent DNase [Populus tomentosa] gi|60476854|gb|AAX21543.1|
Domains
9
Lj2g3v2843390.1
– Ca(2+)-dependent DNase [Populus tomentosa] gi|60476854|gb|AAX21543.1|
Domains
9
LotjaGi1g1v0072600.1
– Nuclease; TAIR: AT2G40410.2 Ca(2+)-dependent nuclease family protein; Swiss-Prot: sp|F4IH31|CAN2_ARATH Staphylococcal-like nuclease CAN2; TrEMBL-Plants: tr|I3SQI6|I3SQI6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0072600
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TMhelix TMHMM 1 33.33