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IPR002140 is a Ribosome maturation protein Sdo1/SBDS.
<p>The proteins in this entry are highly conserved in species ranging from archaea to vertebrates and plants [[cite:PUB00020303]]. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS, OMIM 260400) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities. It is characterised by bone marrow failure and leukemia predisposition [[cite:PUB00045126]]. SBDS is required for the assembly of mature ribosomes and ribosome biogenesis [[cite:PUB00076340]].</p> <p>Homologue of SBDS from budding yeast is known as Sdo1, which is a guanine nucleotide exchange factor (GEF) involved in ribosome maturation. Together with the EF-2-like GTPase RIA1 (EfI1), it triggers the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, allowing the assembly of mature ribosomes [[cite:PUB00076339]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Mature ribosome assembly | The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ribosome maturation protein SBDS-like [Glycine max] gi|356552763|ref|XP_003544732.1| | 17 | ||
| – | PREDICTED: ribosome maturation protein SBDS-like [Cicer arietinum] gi|502163779|ref|XP_004512947.1| | 7 | ||
| – | PREDICTED: ribosome maturation protein SBDS-like [Cicer arietinum] gi|502163779|ref|XP_004512947.1| | 7 | ||
| – | Ribosome maturation protein SBDS; TAIR: AT1G43860.1 sequence-specific DNA binding transcription factor; Swiss-Prot: sp|P70122|SBDS_MOUSE Ribosome maturation protein SBDS; TrEMBL-Plants: tr|I3SB34|I3SB34_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0167500 | 22 | ||
| – | Ribosome maturation protein SBDS; TAIR: AT1G43860.1 sequence-specific DNA binding transcription factor; Swiss-Prot: sp|P70122|SBDS_MOUSE Ribosome maturation protein SBDS; TrEMBL-Plants: tr|I3SB34|I3SB34_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0306500 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |