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IPR039100

Source: InterPro

Description

IPR039100 is a Ribosome maturation protein Sdo1/SBDS-like.

<p>Shwachman-Bodian-Diamond syndrome (SDS) is an autosomal disorder with pancreatic, skeletal and bone marrow deficiencies and a predisposition to hematological dysfunction. The syndrome is associated with mutations in the SBDS gene, which encodes a protein that is required for biogenesis of the 60S ribosomal subunit and activation of the ribosome [[cite:PUB00088931]]. Maturation of the ribosomal 60S subunit requires SBDS and the GTPase EFL1, which release the anti-association factor eIF6 from the surface of the ribosomal subunit 60S [[cite:PUB00088932]]. In yeast, SBDS is known as Sdo1, which with the EF-2-like GTPase Ria1, may trigger the GTP-dependent release of Tif6 from 60S pre-ribosomes in the cytoplasm, thereby activating them [[cite:PUB00045126]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0167500.1
– Ribosome maturation protein SBDS; TAIR: AT1G43860.1 sequence-specific DNA binding transcription factor; Swiss-Prot: sp|P70122|SBDS_MOUSE Ribosome maturation protein SBDS; TrEMBL-Plants: tr|I3SB34|I3SB34_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0167500
Domains
22
LotjaGi4g1v0306500.1
– Ribosome maturation protein SBDS; TAIR: AT1G43860.1 sequence-specific DNA binding transcription factor; Swiss-Prot: sp|P70122|SBDS_MOUSE Ribosome maturation protein SBDS; TrEMBL-Plants: tr|I3SB34|I3SB34_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0306500
Domains
22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00