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IPR002591 is a Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase.
<p>This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1/alkaline phosphodiesterase I/nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulphate bonds in NAD, deoxynucleotides and nucleotide sugars [[cite:PUB00001983], [cite:PUB00097865]]. Another member of this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity [[cite:PUB00002881], [cite:PUB00097864]]. The alignment encompasses the active site [[cite:PUB00002950], [cite:PUB00002881]]. Also present within this family is 60kDa Ca2-ATPase from Myroides odoratus [[cite:PUB00002981]].</p> <p>This entry also hits a number of ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis [[cite:PUB00087462], [cite:PUB00087464]].</p> <p>N-acetylglucosamine-6-O-sulfatase is another member of this family that catalyses the hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units and plays a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the gastrointestinal tract [[cite:PUB00151894], [cite:PUB00100963]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: GPI ethanolamine phosphate transferase 3-like [Glycine max] gi|356545808|ref|XP_003541326.1| | 18 | ||
| – | PREDICTED: GPI ethanolamine phosphate transferase 3-like [Glycine max] gi|356545808|ref|XP_003541326.1| | 16 | ||
| – | PREDICTED: GPI ethanolamine phosphate transferase 3-like [Glycine max] gi|356545808|ref|XP_003541326.1| | 18 | ||
| – | Ectonucleotide pyrophosphatase/phosphodiesterase family member [Medicago truncatula] gi|357501305|ref|XP_003620941.1| | 13 | ||
| – | PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [Vitis vinifera] gi|225444938|ref|XP_002282308.1| | 8 | ||
| – | Ectonucleotide pyrophosphatase/phosphodiesterase family member [Medicago truncatula] gi|357501305|ref|XP_003620941.1| | 14 | ||
| – | Nucleotide pyrophosphatase-like protein [Spinacia oleracea] gi|12081942|dbj|BAB20681.1| | 12 | ||
| – | PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [Glycine max] gi|356511413|ref|XP_003524421.1| | 13 | ||
| – | GPI ethanolamine phosphate transferase 1; TAIR: AT3G01380.2 sulfatase and phosphatidylinositolglycan class N domain-containing protein; Swiss-Prot: sp|Q2U0S9|MCD4_ASPOR GPI ethanolamine phosphate transferase 1; TrEMBL-Plants: tr|K7K2J4|K7K2J4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0604500 | 14 | ||
| – | GPI ethanolamine phosphate transferase; TAIR: AT5G17250.1 Alkaline-phosphatase-like family protein; Swiss-Prot: sp|Q8TEQ8|PIGO_HUMAN GPI ethanolamine phosphate transferase 3; TrEMBL-Plants: tr|A0A0R0GV98|A0A0R0GV98_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0125700 | 14 | ||
| – | Ectonucleotide pyrophosphatase/phosphodiesterase; TAIR: AT4G29680.1 Alkaline-phosphatase-like family protein; Swiss-Prot: sp|O14638|ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; TrEMBL-Plants: tr|G7KJV4|G7KJV4_MEDTR Ectonucleotide pyrophosphatase/phosphodiesterase; Found in the gene: LotjaGi2g1v0233400 | 14 | ||
| – | Ectonucleotide pyrophosphatase/phosphodiesterase; TAIR: AT4G29680.1 Alkaline-phosphatase-like family protein; Swiss-Prot: sp|J3SEZ3|PDE1_CROAD Venom phosphodiesterase 1; TrEMBL-Plants: tr|A0A1J7GU48|A0A1J7GU48_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0233500_LC | 15 | ||
| – | Ectonucleotide pyrophosphatase/phosphodiesterase; TAIR: AT4G29680.1 Alkaline-phosphatase-like family protein; Swiss-Prot: sp|J3SEZ3|PDE1_CROAD Venom phosphodiesterase 1; TrEMBL-Plants: tr|A0A1J7GU48|A0A1J7GU48_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0233600 | 13 | ||
| – | GPI ethanolamine phosphate transferase 2; TAIR: AT2G22530.1 Alkaline-phosphatase-like family protein; Swiss-Prot: sp|Q8TGB2|GPI7_CANAL GPI ethanolamine phosphate transferase 2; TrEMBL-Plants: tr|I1J516|I1J516_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0326900 | 13 | ||
| – | GPI ethanolamine phosphate transferase; TAIR: AT5G17250.1 Alkaline-phosphatase-like family protein; Swiss-Prot: sp|Q8TEQ8|PIGO_HUMAN GPI ethanolamine phosphate transferase 3; TrEMBL-Plants: tr|A0A0R0GV98|A0A0R0GV98_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0317600 | 14 | ||
| – | Ectonucleotide pyrophosphatase/phosphodiesterase; TAIR: AT4G29680.1 Alkaline-phosphatase-like family protein; Swiss-Prot: sp|J3SEZ3|PDE1_CROAD Venom phosphodiesterase 1; TrEMBL-Plants: tr|V7CTL4|V7CTL4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0440700 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.25 |