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IPR007070 is a GPI ethanolamine phosphate transferase 1.
<p>This entry represents GPI ethanolamine phosphate transferase 1 enzymes, including the yeast enzyme MCD4 and the mammalian homolgoue PIG-N (also known as phosphatidylinositolglycan class N) [[cite:PUB00008732], [cite:PUB00008733]]. These enzymes are multi-pass endoplasmic reticulum membrane proteins involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. These enzymes transfer ethanolamine phosphate to the first alpha-1,4-linked mannose of the GPI precursor of the GPI-anchor. Ethanolamine phosphate on the alpha-1,4-linked mannose is essential for further mannosylation by GPI10 and is necessary for an efficient recognition of GPI lipids and GPI proteins by the GPI transamidase, for the efficient transport of GPI anchored proteins from endoplasmic reticulum to Golgi and for the physiological incorporation of ceramides into GPI anchors by lipid remodeling. MCD4 is also involved in non-mitochondrial ATP movements across the membrane and participates in Golgi and endoplasmic reticulum function, and is required for the incorporation of BGL2 into the cell wall.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. | ||
| Biological process | GPI anchor biosynthetic process | The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. | ||
| Molecular function | Mannose-ethanolamine phosphotransferase activity | Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | GPI ethanolamine phosphate transferase 1; TAIR: AT3G01380.2 sulfatase and phosphatidylinositolglycan class N domain-containing protein; Swiss-Prot: sp|Q2U0S9|MCD4_ASPOR GPI ethanolamine phosphate transferase 1; TrEMBL-Plants: tr|K7K2J4|K7K2J4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0604500 | 14 | ||
| – | GPI ethanolamine phosphate transferase 1; TAIR: AT3G01380.1 sulfatase and phosphatidylinositolglycan class N domain-containing protein; Swiss-Prot: sp|Q9R1S3|PIGN_MOUSE GPI ethanolamine phosphate transferase 1; TrEMBL-Plants: tr|K7K2J4|K7K2J4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0604500 | 8 | ||
| – | GPI ethanolamine phosphate transferase 1; TAIR: AT3G01380.2 sulfatase and phosphatidylinositolglycan class N domain-containing protein; Swiss-Prot: sp|Q5AXD1|MCD4_EMENI GPI ethanolamine phosphate transferase 1; TrEMBL-Plants: tr|A0A078IDZ6|A0A078IDZ6_BRANA BnaC05g48780D protein; Found in the gene: LotjaGi1g1v0604500 | 14 | ||
| – | GPI ethanolamine phosphate transferase 1; TAIR: AT3G01380.2 sulfatase and phosphatidylinositolglycan class N domain-containing protein; Swiss-Prot: sp|Q2U0S9|MCD4_ASPOR GPI ethanolamine phosphate transferase 1; TrEMBL-Plants: tr|K7K2J4|K7K2J4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0604500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16020 | CDD | 1 | 25.00 |