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IPR002698 is a 5-formyltetrahydrofolate cyclo-ligase.
<p>5-formyltetrahydrofolate cyclo-ligase or methenyl-THF synthetase [ec:6.3.3.2] catalyses the interchange of 5-formyltetrahydrofolate (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg<sup>2</sup>[[cite:PUB00001860]]. 5-FTHF is used in chemotherapy where it is clinically known as Leucovorin [[cite:PUB00002860]].</p> <p>This entry also includes the 5-formyltetrahydrofolate cyclo-ligase-like protein COG0212 (At1g76730) from Arabidopsis. It does not possess the 5-formyltetrahydrofolate cyclo-ligase activity in vitro and does not complement the growth defect or the characteristic 5-formyltetrahydrofolate accumulation of a 5-FCL-deficient Escherichia coli strain. Instead, it may play a role in thiamin metabolism [[cite:PUB00070331]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: methenyltetrahydrofolate synthase domain-containing protein-like [Cicer arietinum] gi|502164511|ref|XP_004513147.1| | 8 | ||
| – | PREDICTED: 5-formyltetrahydrofolate cyclo-ligase-like isoform X1 [Cicer arietinum] gi|502093532|ref|XP_004489971.1| | 8 | ||
| – | 5-formyltetrahydrofolate cyclo-ligase; TAIR: AT5G13050.1 5-formyltetrahydrofolate cycloligase; Swiss-Prot: sp|Q8L539|5FCL_ARATH 5-formyltetrahydrofolate cyclo-ligase, mitochondrial; TrEMBL-Plants: tr|A0A0B2QHY4|A0A0B2QHY4_GLYSO 5-formyltetrahydrofolate cyclo-ligase; Found in the gene: LotjaGi1g1v0186100 | 9 | ||
| – | 5-formyltetrahydrofolate cyclo-ligase; TAIR: AT1G76730.1 NagB/RpiA/CoA transferase-like superfamily protein; Swiss-Prot: sp|Q9SRE0|5FCLL_ARATH 5-formyltetrahydrofolate cyclo-ligase-like protein COG0212; TrEMBL-Plants: tr|A0A0L9VLB2|A0A0L9VLB2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0128300 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |