Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR002809

Source: InterPro

Description

IPR002809 is a Integral membrane protein EMC3/TMCO1-like.

<p>This entry represents a group of eukaryotic and archaeal proteins from the Oxa1 superfamily which includes a group of proteins that function in different contexts as transmembrane domains (TMD) insertases and/or as intramembrane chaperones to facilitate membrane protein folding and assembly [[cite:PUB00151274], [cite:PUB00097241]]. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding [[cite:PUB00061987]], and TMCO1, a component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes [[cite:PUB00097241], [cite:PUB00103609]]. Previously, it has been reported that TMCO1 is a ER calcium load-activated calcium channel [[cite:PUB00081416]]. TMCO1 is required for the normal development of corpus callosum as it plays a role in Ca2 homeostasis [[cite:PUB00151275]]. Archaeal members may function as insertases of the archaeal plasma membrane [[cite:PUB00086930]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016020
Cellular component Membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj0g3v0284669.1
– Transmembrane and coiled-coil domain-containing protein [Medicago truncatula] gi|357508575|ref|XP_003624576.1|
Domains
11
Lj5g3v1326710.1
– PREDICTED: transmembrane protein 111-like [Glycine max] gi|356566401|ref|XP_003551420.1|
Domains
10
Lj5g3v1327760.1
– PREDICTED: transmembrane protein 111-like [Glycine max] gi|356566401|ref|XP_003551420.1|
Domains
10
LotjaGi1g1v0638400.1
– Transmembrane and coiled-coil domains protein 1; TAIR: AT5G06660.1 transmembrane/coiled-coil protein (Protein of unknown function DUF106, transmembrane); Swiss-Prot: sp|Q3T0N3|TMCO1_BOVIN Calcium load-activated calcium channel; TrEMBL-Plants: tr|I3S180|I3S180_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0638400
Domains
11
LotjaGi1g1v0638400.2
– Transmembrane and coiled-coil domains protein 1; TAIR: AT5G06660.1 transmembrane/coiled-coil protein (Protein of unknown function DUF106, transmembrane); Swiss-Prot: sp|Q3T0N3|TMCO1_BOVIN Calcium load-activated calcium channel; TrEMBL-Plants: tr|I3S180|I3S180_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0638400
Domains
11
LotjaGi1g1v0638400.3
– Transmembrane and coiled-coil domains protein 1; TAIR: AT5G06660.1 transmembrane/coiled-coil protein (Protein of unknown function DUF106, transmembrane); Swiss-Prot: sp|Q3T0N3|TMCO1_BOVIN Calcium load-activated calcium channel; TrEMBL-Plants: tr|I3S180|I3S180_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0638400
Domains
11
LotjaGi5g1v0207000.1
– ER membrane protein complex subunit 3; TAIR: AT4G12590.1 ER membrane protein complex subunit-like protein (Protein of unknown function DUF106, transmembrane); Swiss-Prot: sp|Q7SXW4|EMC3_DANRE ER membrane protein complex subunit 3; TrEMBL-Plants: tr|I3S7X8|I3S7X8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0207000
Domains
11
LotjaGi5g1v0207000.2
– ER membrane protein complex subunit 3; TAIR: AT4G12590.1 ER membrane protein complex subunit-like protein (Protein of unknown function DUF106, transmembrane); Swiss-Prot: sp|Q7SXW4|EMC3_DANRE ER membrane protein complex subunit 3; TrEMBL-Plants: tr|I3S7X8|I3S7X8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0207000
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 12.50