Description

IPR003020 is a Bicarbonate transporter, eukaryotic.

<p>Bicarbonate (HCO₃^-) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO₃^-transport modes. Anion exchanger proteins exchange HCO₃^-for Cl^-in a reversible, electroneutral manner [[cite:PUB00005997]]. Na⁺/HCO₃^-co-transport proteins mediate the coupled movement of Na⁺and HCO₃^-across plasma membranes, often in an electrogenic manner [[cite:PUB00018713]]. Na⁺driven Cl^-/HCO₃^-exchange and K⁺/HCO₃^-exchange activities have also been detected in certain cell types, although the molecular identities of the proteins responsible remain to be determined.</p> <p>Sequence analysis of the two families of HCO₃^-transporters that have been cloned to date (the anion exchangers and Na⁺/HCO₃^-co-transporters) reveals that they are homologous. This is not entirely unexpected, given that they both transport HCO₃^-and are inhibited by a class of pharmacological agents called disulphonic stilbenes [[cite:PUB00006023]]. They share around ~25-30% sequence identity, which is distributed along their entire sequence length, and have similar predicted membrane topologies, suggesting they have ~10 transmembrane (TM) domains.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 27

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: