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IPR003043 is a Uroporphiryn-III C-methyltransferase, conserved site.
<p>Uroporphyrin-III C-methyltransferase ([ec:2.1.1.107])(SUMT) [[cite:PUB00002147], [cite:PUB00002148]] catalyses the transfer of two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. SUMT is the first enzyme specific to the cobalamin pathway and precorrin-2 is a common intermediate in the biosynthesis of corrinoids such as vitamin B12, siroheme and coenzyme F430.</p> <p>The sequences of SUMT from a variety of eubacterial and archaebacterial species are currently available. In species such as Bacillus megaterium (gene cobA), Pseudomonas denitrificans (cobA) or Methanobacterium ivanovii (gene corA) SUMT is a protein of about 25 to 30 Kd. In Escherichia coli and related bacteria, the cysG protein, which is involved in the biosynthesis of siroheme, is a multifunctional protein composed of a N-terminal domain, probably involved in transforming precorrin-2 into siroheme, and a C-terminal domain which has SUMT activity.</p> <p>The sequence of SUMT is related to that of a number of P. denitrificans and Salmonella typhimurium enzymes involved in the biosynthesis of cobalamin which also seem to be SAM-dependent methyltransferases [[cite:PUB00002120], [cite:PUB00015329]]. The similarity is especially strong with two of these enzymes: cobI/cbiL which encodes S-adenosyl-L-methionine--precorrin-2 methyltransferase and cobM/cbiF whose exact function is not known.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: siroheme synthase 2-like isoform X1 [Cicer arietinum] gi|502152962|ref|XP_004509171.1| | 14 | ||
| – | PREDICTED: siroheme synthase 2-like isoform X1 [Cicer arietinum] gi|502152962|ref|XP_004509171.1| | 16 | ||
| – | Siroheme synthase; TAIR: AT5G40850.1 urophorphyrin methylase 1; Swiss-Prot: sp|Q02NA3|CYSG_PSEAB Siroheme synthase; TrEMBL-Plants: tr|A0A1J7HG28|A0A1J7HG28_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0125200 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11642 | CDD | 1 | 33.33 |