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IPR006366

Source: InterPro

Description

IPR006366 is a Uroporphyrin-III C-methyltransferase.

<p>SUMT, an enzyme of the cobalamin and siroheme biosynthetic pathway, catalyses the transformation of uroporphyrinogen III into precorrin-2. It transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. SUMT is the first enzyme committed to the biosynthesis of siroheme or cobalamin (vitamin B12), and precorrin-2 is a common intermediate in the biosynthesis of corrinoids such as vitamin B12, siroheme and coenzyme F430 [[cite:PUB00030902], [cite:PUB00037925]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008168
Molecular function Methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
Subterm of
GO:0019354
Biological process Siroheme biosynthetic process The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj3g3v0893740.1
– PREDICTED: siroheme synthase 2-like isoform X1 [Cicer arietinum] gi|502152962|ref|XP_004509171.1|
Domains
16
LotjaGi3g1v0125200.1
– Siroheme synthase; TAIR: AT5G40850.1 urophorphyrin methylase 1; Swiss-Prot: sp|Q02NA3|CYSG_PSEAB Siroheme synthase; TrEMBL-Plants: tr|A0A1J7HG28|A0A1J7HG28_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0125200
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd11642 CDD 1 50.00